{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:48:40Z","timestamp":1789652920190,"version":"4.0.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T00:00:00Z","timestamp":1407801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Abstract<\/jats:title>\n \n Background and objectives<\/jats:title>\n \n Little is known about the prevalence of anxiety in interstitial lung disease (\n ILD<\/jats:styled-content>\n ), and the contributors to depression are not clear. The aim of this study was to determine the prevalence and predictors of anxiety and depression in people with\n ILD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n One hundred and twenty\u2010four individuals with\n ILD<\/jats:styled-content>\n (age 64 years (standard deviation 12), 48 idiopathic pulmonary fibrosis) participated. Anxiety and depression were assessed using the\n H<\/jats:styled-content>\n ospital\n A<\/jats:styled-content>\n nxiety and\n D<\/jats:styled-content>\n epression\n S<\/jats:styled-content>\n cale to determine likely cases and borderline cases. Associations with demographic data, respiratory function, 6\u2010min walk and\n M<\/jats:styled-content>\n odified\n M<\/jats:styled-content>\n edical\n R<\/jats:styled-content>\n esearch\n C<\/jats:styled-content>\n ouncil\n D<\/jats:styled-content>\n yspnoea\n S<\/jats:styled-content>\n cale (\n MMRC<\/jats:styled-content>\n ) were examined.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The prevalence of anxiety was 31%, with clinically significant anxiety in 12%. Depression was present in 23% of individuals, with 7% having clinically significant depression. Independent predictors of anxiety were a higher\n MMRC<\/jats:styled-content>\n score (\n P<\/jats:italic>\n \u2009=\u20090.005, odds ratio (\n OR<\/jats:styled-content>\n ) for case 2.60, 95% confidence interval 1.37 to 4.92) and higher nadir SpO\n 2<\/jats:sub>\n during walking (\n P<\/jats:italic>\n \u2009=\u20090.003,\n OR<\/jats:styled-content>\n for case 1.16, 1.04\u20131.30). Independent predictors of depression were a higher\n MMRC<\/jats:styled-content>\n score (\n P<\/jats:italic>\n \u2009=\u20090.006, case\n OR<\/jats:styled-content>\n 3.84, 1.25\u201311.78, borderline case\n OR<\/jats:styled-content>\n 2.44, 1.14\u20135.19) and a greater number of comorbidities (\n P<\/jats:italic>\n \u2009=\u20090.003, case\n OR<\/jats:styled-content>\n 2.02, 0.97\u20134.21, borderline case\n OR<\/jats:styled-content>\n 2.26, 1.30\u20133.93).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Anxiety and depression are present in a significant minority of individuals with\n ILD<\/jats:styled-content>\n . Dyspnoea and comorbidities are important contributors that may be amenable to intervention.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.12360","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T05:05:39Z","timestamp":1407819939000},"page":"1215-1221","source":"Crossref","is-referenced-by-count":149,"title":["Dyspnoea and comorbidity contribute to anxiety and depression in interstitial lung disease"],"prefix":"10.1111","volume":"19","author":[{"given":"Anne E.","family":"Holland","sequence":"first","affiliation":[{"name":"Department of Physiotherapy Alfred Health Melbourne Victoria Australia"},{"name":"Department of Physiotherapy La Trobe University Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep Austin Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Julio F.","family":"Fiore","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Alfred Health Melbourne Victoria Australia"},{"name":"Department of Physiotherapy La Trobe University Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep Austin Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily C.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy La Trobe University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Goh","sequence":"additional","affiliation":[{"name":"Institute for Breathing and Sleep Austin Health Melbourne Victoria Australia"},{"name":"Department of Respiratory and Sleep Medicine Austin Health Melbourne Victoria Australia"},{"name":"Department of Allergy Immunology and Respiratory Medicine Alfred Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Westall","sequence":"additional","affiliation":[{"name":"Department of Allergy Immunology and Respiratory Medicine Alfred Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Symons","sequence":"additional","affiliation":[{"name":"Department of Allergy Immunology and Respiratory Medicine Alfred Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leona","family":"Dowman","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy La Trobe University Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep Austin Health Melbourne Victoria Australia"},{"name":"Department of Physiotherapy Austin Health Melbourne Victoria 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