{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:01:05Z","timestamp":1774119665173,"version":"3.50.1"},"reference-count":75,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T00:00:00Z","timestamp":1409702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The number of lung transplants performed globally continues to increase year after year. Despite this growing experience, long\u2010term outcomes following lung transplantation continue to fall far short of that described in other solid\u2010organ transplant settings. Chronic lung allograft dysfunction (<jats:styled-content style=\"fixed-case\">CLAD<\/jats:styled-content>) remains common and is the end result of exposure to a multitude of potentially injurious insults that include alloreactivity and infection among others. Central to any description of the clinical performance of the transplanted lung is an assessment of its physiology by pulmonary function testing. Spirometry and the evaluation of forced expiratory volume in 1\u2009s and forced vital capacity, remain core indices that are measured as part of routine clinical follow\u2010up. Spirometry, while reproducible in detecting lung allograft dysfunction, lacks specificity in differentiating the different complications of lung transplantation such as rejection, infection and bronchiolitis obliterans. However, interpretation of spirometry is central to defining the different \u2018chronic rejection\u2019 phenotypes. It is becoming apparent that the maximal lung function achieved following transplantation, as measured by spirometry, is influenced by a number of donor and recipient factors as well as the type of surgery performed (single vs double vs lobar lung transplant). In this review, we discuss the wide range of variables that need to be considered when interpreting lung function testing in lung transplant recipients. Finally, we review a number of novel measurements of pulmonary function that may in the future serve as better biomarkers to detect and diagnose the cause of the failing lung allograft.<\/jats:p>","DOI":"10.1111\/resp.12370","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T12:29:42Z","timestamp":1409833782000},"page":"1097-1105","source":"Crossref","is-referenced-by-count":12,"title":["Lung transplantation in adults and children: Putting lung function into perspective"],"prefix":"10.1111","volume":"19","author":[{"given":"Bruce Robert","family":"Thompson","sequence":"first","affiliation":[{"name":"Lung Transplant Service Department of Allergy, Immunology and Respiratory Medicine The Alfred Hospital  Melbourne Victoria Australia"},{"name":"Department of Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen Philip","family":"Westall","sequence":"additional","affiliation":[{"name":"Lung Transplant Service Department of Allergy, Immunology and Respiratory Medicine The Alfred Hospital  Melbourne Victoria Australia"},{"name":"Department of Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda","family":"Paraskeva","sequence":"additional","affiliation":[{"name":"Lung Transplant Service Department of Allergy, Immunology and Respiratory Medicine The Alfred Hospital  Melbourne Victoria Australia"},{"name":"Department of Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Ian","family":"Snell","sequence":"additional","affiliation":[{"name":"Lung Transplant Service Department of Allergy, Immunology and Respiratory Medicine The Alfred Hospital  Melbourne Victoria Australia"},{"name":"Department of Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.08.004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03849.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)00398-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.07.014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2838"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.9912063"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.03.011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2011.02.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1348461"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0737"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00294402"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.11.032"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.07.002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.12.009"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0767"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201306-1155OC"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.1994.tb00818.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(86)90046-0"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.09.014"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.03.051"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2008.tb01957.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0022-5223(19)35528-X","article-title":"Growth potential of the immature transplanted lung. 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