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There is little doubt that acute bronchiolitis is associated with an increased risk of recurrent wheezing throughout the primary school years although the direction of causality\u2014i.e. whether bronchiolitis in infancy leads to asthma or it merely represents the first clinical presentation of predisposition to asthma\u2014is uncertain. Existing evidence suggests that both host factors (e.g. prematurity, atopic predisposition) and acute viral infection characteristics (e.g. type of virus, severity) are operating in this relationship, perhaps with variable involvement in different individuals. Further clarification of these issues will help paediatricians provide evidence\u2010based information regarding the long\u2010term prognosis of this common disease to the families, and at the same time, it will facilitate prophylactic approaches and therapeutic strategies.<\/jats:p>","DOI":"10.1111\/resp.12371","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T10:36:37Z","timestamp":1408444597000},"page":"1158-1164","source":"Crossref","is-referenced-by-count":10,"title":["\u2018They said it was bronchiolitis; is it going to turn into asthma doctor?\u2019"],"prefix":"10.1111","volume":"19","author":[{"given":"Dimos","family":"Gidaris","sequence":"first","affiliation":[{"name":"1st Paediatric Department, Aristotle University of Thessaloniki Hippokrateion General Hospital Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don","family":"Urquhart","sequence":"additional","affiliation":[{"name":"Royal Hospital for Sick Children Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Anthracopoulos","sequence":"additional","affiliation":[{"name":"Respiratory Unit, Department of Pediatrics University of Patras Patras Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2009.03.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60206-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21321"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39374.600081.AD"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/prrv.2000.0052"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb00359.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.133967"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.01.011"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2012.02825.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328360bd2e"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31829061e8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200802-309OC"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20597"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.01.024"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69077-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.44.1.1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1183\/20734735.003911","article-title":"Bronchiolitis in infants and wheeze in preschool children","volume":"8","author":"Midulla F","year":"2011","journal-title":"Breathe"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00188210"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22675"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10321-5"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.037"},{"key":"e_1_2_10_23_1","first-page":"305","volume-title":"ERS Handbook of Paediatric Respiratory Medicine","author":"Midulla F","year":"2013"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00002108"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201008-1331ED"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22724"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00166511"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00170511"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.013391"},{"key":"e_1_2_10_30_1","first-page":"1172","article-title":"Classification and pharmacological treatment of preschool wheezing: changes since","volume":"2014","author":"Brand PLP","year":"2008","journal-title":"Eur. 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