{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:14:38Z","timestamp":1771046078186,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T00:00:00Z","timestamp":1409616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health - Malaysia","award":["NMRR-09-1075-5016"],"award-info":[{"award-number":["NMRR-09-1075-5016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>We evaluated the efficacy of a 12\u2010week oral treatment with azithromycin in adult patients with bronchiectasis. The objectives were to demonstrate that this treatment reduces sputum volume, improves quality of life and to assess the lengths of effects after cessation of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010eight patients with bronchiectasis confirmed by high\u2010resolution computed tomography were included in this study. Subjects received oral azithromycin or placebo in a randomized manner for 12 weeks followed by placebo for another 12 weeks. Sputum volume, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>t <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>eorge's <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>espiratory <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uestionnaire (<jats:styled-content style=\"fixed-case\">SGRQ<\/jats:styled-content>) score and spirometry were recorded at baseline, 12 weeks and 24 weeks, respectively. End\u2010point measurements were compared from baseline to the end of each study phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010eight subjects were included in the analysis. Mean 24\u2010h sputum volume significantly decreased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) during the active treatment phase and remained low during the control phase (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The mean <jats:styled-content style=\"fixed-case\">SGRQ<\/jats:styled-content> total score with azithromycin decreased (i.e. improved health status) from baseline by more than the 4 points at the end of 12 and 24 weeks. Lung functions remained stable during oral azithromycin therapy and the subsequent control phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Twelve weeks administration of azithromycin in bronchiectasis produces significant reductions in mean sputum volume, health status and stabilization of lung function values. Sputum volume reduction and the improvement of quality of life were sustained for 12 weeks after cessation of azithromycin. (Clinicaltrials.gov number <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>02107274).<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12375","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T00:59:14Z","timestamp":1409705954000},"page":"1178-1182","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy of azithromycin in the treatment of bronchiectasis"],"prefix":"10.1111","volume":"19","author":[{"given":"Albert I.","family":"Lourdesamy Anthony","sequence":"first","affiliation":[{"name":"Respiratory Unit Hospital Taiping  Taiping Perak Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umadevi","family":"Muthukumaru","sequence":"additional","affiliation":[{"name":"Respiratory Unit Hospital Taiping  Taiping Perak Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2006.01219.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13b24.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.06.005"},{"key":"e_1_2_8_5_1","first-page":"540","article-title":"Prophylactic antibiotic treatment of bronchiectasis with azithromycin","volume":"59","author":"Davies G","year":"2004","journal-title":"Thorax"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00151829-200504020-00005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-200050513"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.12375","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.12375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T11:37:50Z","timestamp":1695987470000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.12375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,2]]},"references-count":6,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/resp.12375"],"URL":"https:\/\/doi.org\/10.1111\/resp.12375","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,2]]}}}