{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:55:52Z","timestamp":1760622952158},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T00:00:00Z","timestamp":1412035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Nontuberculous mycobacterial (<jats:styled-content style=\"fixed-case\">NTM<\/jats:styled-content>) lung disease secondary to cystic fibrosis (<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>) has been reported, but there is limited data about <jats:styled-content style=\"fixed-case\">NTM<\/jats:styled-content> prevalence in non\u2010<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> bronchiectasis. We retrospectively investigated the prevalence of <jats:styled-content style=\"fixed-case\">NTM<\/jats:styled-content> associated with diffuse panbronchiolitis (<jats:styled-content style=\"fixed-case\">DPB<\/jats:styled-content>), a disorder also characterized by reduced mucociliary clearance with bronchiectasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed mycobacterial cultures, patient characteristics and computed tomography findings of 33 patients with <jats:styled-content style=\"fixed-case\">DPB<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2000 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2012. Prevalence was based on at least one positive <jats:styled-content style=\"fixed-case\">NTM<\/jats:styled-content> culture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean patient age was 51.5 years. During a mean 162.8\u2010month follow\u2010up, the prevalence of <jats:styled-content style=\"fixed-case\">NTM<\/jats:styled-content> in sputum was 21.2% (seven patients). Of the seven positive patients, six had <jats:styled-content style=\"fixed-case\"><jats:italic>M<\/jats:italic><\/jats:styled-content><jats:italic>ycobacterium avium<\/jats:italic> complex, one had <jats:styled-content style=\"fixed-case\"><jats:italic>M<\/jats:italic><\/jats:styled-content><jats:italic>.\u2009kansasii<\/jats:italic> and <jats:styled-content style=\"fixed-case\"><jats:italic>M<\/jats:italic><\/jats:styled-content><jats:italic>.\u2009chelonae<\/jats:italic> co\u2010cultured with <jats:styled-content style=\"fixed-case\"><jats:italic>M<\/jats:italic><\/jats:styled-content><jats:italic>.\u2009avium<\/jats:italic> complex. Three patients were positive twice, and two had positive smears. The mean time from <jats:styled-content style=\"fixed-case\">DPB<\/jats:styled-content> diagnosis to the first positive result was 194.6 months. <jats:styled-content style=\"fixed-case\">NTM<\/jats:styled-content>\u2010positive patients tended to have lower forced expiratory volume in 1\u2009s (% predicted) than <jats:styled-content style=\"fixed-case\">NTM<\/jats:styled-content>\u2010negative patients (50.0% vs 77.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.03), but there were no radiological or clinical differences between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our observations suggest that <jats:styled-content style=\"fixed-case\">NTM<\/jats:styled-content> is found more often in <jats:styled-content style=\"fixed-case\">DPB<\/jats:styled-content>. Defects of mucociliary clearance may predispose individuals to <jats:styled-content style=\"fixed-case\">NTM<\/jats:styled-content> infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12412","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T02:13:51Z","timestamp":1412129631000},"page":"80-86","source":"Crossref","is-referenced-by-count":10,"title":["Nontuberculous mycobacteria in diffuse panbronchiolitis"],"prefix":"10.1111","volume":"20","author":[{"given":"Takahiro","family":"Tsuji","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisaku","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikkoh","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinari","family":"Nakatsuka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kaji","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seishu","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon Hee","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hajiro","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(02)00022-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200207-678OC"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200303-365OC"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.1.70"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.4.1096"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1403.061405"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01257-09"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.68.805.896"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00149805"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.046631"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rce.2011.08.002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1843.2002.00367.x"},{"key":"e_1_2_7_15_1","first-page":"25","volume-title":"Annual Report on the Study of Interstitial Lung Disease in 1980","author":"Odaka M","year":"1981"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.9710075"},{"key":"e_1_2_7_17_1","first-page":"19","article-title":"Historical changes in epidemiology of diffuse panbronchiolitis","volume":"29","author":"Kono C","year":"2012","journal-title":"Sarcoidosis Vasc. 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