{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T19:53:10Z","timestamp":1781121190958,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NH&MRC"},{"name":"Western Australia Cancer and Palliative Care Network (WACPCN)"},{"name":"LIWA, Australia"},{"name":"New South Wales Dust Disease Board, Sir Charles Gairdner Research Advisory Committee"},{"name":"LIWA Westcare Grants"},{"DOI":"10.13039\/501100001170","name":"Cancer Council of Western Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Flexi\u2010rigid pleuroscopy is a useful tool in the work\u2010up of pleural effusions, but pleural biopsy using flexible forceps can be difficult in some patients. This study evaluated the feasibility, safety and diagnostic value of using a flexible cryoprobe to obtain parietal pleural biopsies during pleuroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010centre retrospective study. In patients undergoing diagnostic pleuroscopy, pleural biopsy using flexible forceps, followed by a flexible cryoprobe introduced through the pleuroscope, were performed. A pathologist independently reviewed all biopsies. Any complications, particularly bleeding, were recorded. All patients were followed up for \u22656 months (median 12 months (range 7\u201326)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two patients (21 males; median age 72 years; 14 right\u2010sided effusions) were included. All underwent flexible forceps biopsies (<jats:styled-content style=\"fixed-case\">FFB<\/jats:styled-content>) and cryoprobe biopsies (<jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>) of pleura. <jats:styled-content style=\"fixed-case\">FFB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> established a definitive diagnosis in 20\/22 (90%). <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> successfully obtained pleural tissue suitable for histopathological analysis in all patients. <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> was larger than <jats:styled-content style=\"fixed-case\">FFB<\/jats:styled-content> (median, 25\u201375 IQR of 10, 7\u201315.8mm vs 4, 3\u20138mm), and had better preserved cellular architecture and tissue integrity. Crush artefacts were less common with <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> (2\/22) compared with <jats:styled-content style=\"fixed-case\">FFB<\/jats:styled-content> (21\/22). No significant bleeding was reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> during flexi\u2010rigid pleuroscopy is feasible, safe and effective. Its routine use during flexi\u2010rigid pleuroscopy requires further evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12441","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:07:52Z","timestamp":1418083672000},"page":"327-332","source":"Crossref","is-referenced-by-count":49,"title":["Pleuroscopic cryoprobe biopsies of the pleura: A feasibility and safety study"],"prefix":"10.1111","volume":"20","author":[{"given":"Rajesh","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth Western Australia Australia"},{"name":"Centre for Asthma, Allergy and Respiratory Research School of Medicine and Pharmacology University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanka","family":"Karunarathne","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barton","family":"Jennings","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Morey","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siaw Ming","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology PathWest QE II Medical Centre  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.C. Gary","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth Western Australia Australia"},{"name":"Centre for Asthma, Allergy and Respiratory Research School of Medicine and Pharmacology University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2005.00737.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2007.01144.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.1.150"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12066"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1187"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00014006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000135934"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.69117"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2290"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000203987"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12037"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00013706"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e3283470293"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000083404"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.58.suppl_2.ii8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-008-0263-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.01.057"},{"key":"e_1_2_7_20_1","first-page":"169","article-title":"The long\u2010term follow up of exudative pleural effusion after nondiagnostic thoracoscopy","volume":"11","author":"Janssen J","year":"2004","journal-title":"J. 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