{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T10:47:11Z","timestamp":1756810031833},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T00:00:00Z","timestamp":1416960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research University Project of the Thailand Office of Higher Education Commission"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Limited data exist for the performance of <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uanti<jats:styled-content style=\"fixed-case\">FERON<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> Gold <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>n\u2010tube <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>est (<jats:styled-content style=\"fixed-case\">QFT\u2010IT<\/jats:styled-content>) in comparison to tuberculin skin test (<jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>) for detecting latent tuberculosis (<jats:styled-content style=\"fixed-case\">LTB<\/jats:styled-content>) in patients with human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>) infection from tuberculosis (<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>)\u2010endemic <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sia\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>acific countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort study of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>hai <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients without history of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">LTB<\/jats:styled-content> treatment was conducted from <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2012 through <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2013. Each patient underwent simultaneous <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">QFT\u2010IT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 150 enrolled subjects, the median age was 40 years (range 17\u201365), 53% were male, and the median <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 count was 367\u2009cells\/\u03bcL (range 8\u20131290). Reactive <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> and positive <jats:styled-content style=\"fixed-case\">QFT\u2010IT<\/jats:styled-content> were 16% and 13%, respectively, with low concordance between tests (kappa\u2009=\u20090.26); correlation between <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> reaction size and level of interferon\u2010\u03b3 was moderate (r\u2009=\u20090.34). Independent factors associated with discordant results were long\u2010term smoking (adjusted odds ratio (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>) 5.74; <jats:italic>P<\/jats:italic>\u2009=\u20090.002) for <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>\u2010reactive, <jats:styled-content style=\"fixed-case\">QFT\u2010IT<\/jats:styled-content>\u2010negative subjects, and age greater than 52 years (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 5.56; <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and female gender (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 4.40; <jats:italic>P<\/jats:italic>\u2009=\u20090.04) for <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> non\u2010reactive, <jats:styled-content style=\"fixed-case\">QFT\u2010IT<\/jats:styled-content>\u2010positive subjects. The level of agreement between both tests improved when using a <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> cut\u2010off of \u226510\u2009mm (kappa\u2009=\u20090.39).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>n our setting where <jats:styled-content style=\"fixed-case\">QFT\u2010IT<\/jats:styled-content> is available but has limited use due to cost, <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> with a cut\u2010off of 10\u2009mm for reactivity should be the initial <jats:styled-content style=\"fixed-case\">LTB<\/jats:styled-content> test. <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected women and persons older than 52 years with non\u2010reactive <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> and long\u2010term smokers with reactive <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> may benefit from subsequent <jats:styled-content style=\"fixed-case\">QFT\u2010IT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12442","type":"journal-article","created":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:49:34Z","timestamp":1417049374000},"page":"340-347","source":"Crossref","is-referenced-by-count":15,"title":["Tuberculin skin test and <scp>Q<\/scp>uanti<scp>FERON<\/scp>\u2010<scp>TB<\/scp> Gold <scp>I<\/scp>n\u2010tube <scp>T<\/scp>est for latent tuberculosis in <scp>T<\/scp>hai <scp>HIV<\/scp>\u2010infected adults"],"prefix":"10.1111","volume":"20","author":[{"given":"Thana","family":"Khawcharoenporn","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Faculty of Medicine Thammasat University  Pathumthani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anucha","family":"Apisarnthanarak","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Faculty of Medicine Thammasat University  Pathumthani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjawan","family":"Phetsuksiri","sequence":"additional","affiliation":[{"name":"National Institute of Health Department of Medical Sciences Ministry of Public Health  Nonthaburi Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janisara","family":"Rudeeaneksin","sequence":"additional","affiliation":[{"name":"National Institute of Health Department of Medical Sciences Ministry of Public Health  Nonthaburi Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sopa","family":"Srisungngam","sequence":"additional","affiliation":[{"name":"National Institute of Health Department of Medical Sciences Ministry of Public Health  Nonthaburi Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda M.","family":"Mundy","sequence":"additional","affiliation":[{"name":"LM Mundy GlaxoSmithKline  Collegeville Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31820b07ab"},{"key":"e_1_2_7_3_1","unstructured":"World Health Organization.Guidelines for intensified tuberculosis case\u2010finding and isoniazid preventive therapy for people living with HIV in resource\u2010constrained settings Geneva Switzerland.2011. 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