{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:38:03Z","timestamp":1779399483315,"version":"3.53.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Literature suggests that ultrasound\u2010guided transbronchial needle aspiration (<jats:styled-content style=\"fixed-case\">EBUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TBNA<\/jats:styled-content>) has excellent performance characteristics for diagnosis of sarcoidosis. However, many authors challenge the external validity of <jats:styled-content style=\"fixed-case\">EBUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TBNA<\/jats:styled-content> results, as most studies were performed in referral centres by highly experienced investigators, and included populations with very high sarcoidosis prevalence.<\/jats:p><jats:p>We performed a systematic review and meta\u2010analysis to estimate the role of <jats:styled-content style=\"fixed-case\">EBUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TBNA<\/jats:styled-content> for diagnosis of sarcoidosis in studies enrolling consecutive patients with lymphadenopathy detected at imaging studies, regardless of the suspected underlying clinical aetiology. The <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ubmed, <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>mbase, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>inahl, <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>eb of <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cience and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ochrane <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ibrary databases were screened to identify the pertinent literature. Quality of eligible studies was assessed by <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uality <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment, <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ata <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>bstraction and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ynthesis\u20102 criteria. Pooled diagnostic yield, sensitivity and specificity were calculated, and a summary receiver operating characteristic curve was constructed. Subgroup analysis was planned to identify possible sources of study heterogeneity. Fourteen studies, collectively involving 2097 patients, fulfilled eligibility criteria. The median prevalence of sarcoidosis was 15%. <jats:styled-content style=\"fixed-case\">EBUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TBNA<\/jats:styled-content> had a pooled diagnostic yield of 0.79 (standard deviation, 0.24), a pooled sensitivity of 0.84 (95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 0.79\u20130.88) and a pooled specificity of 1.00 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.99\u20131.00). Only subgroup analysis exploring the influence of study design seemed to influence the observed inter\u2010study heterogeneity for sensitivity, retrospective studies showing worst sensitivity than prospective ones. The results of <jats:styled-content style=\"fixed-case\">EBUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TBNA<\/jats:styled-content> for diagnosis of sarcoidosis in clinically unselected populations are excellent and compare favourably with published results from studies conducted in selected populations. High\u2010quality trials would be needed to evaluate factors possibly explaining the observed heterogeneity in sensitivity.<\/jats:p>","DOI":"10.1111\/resp.12449","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:08:24Z","timestamp":1418083704000},"page":"226-234","source":"Crossref","is-referenced-by-count":77,"title":["Endobronchial ultrasound\u2010guided transbronchial needle aspiration for diagnosis of sarcoidosis in clinically unselected study populations"],"prefix":"10.1111","volume":"20","author":[{"given":"Rocco","family":"Trisolini","sequence":"first","affiliation":[{"name":"Thoracic Endoscopy and Pulmonology Unit Maggiore Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Lazzari Agli","sequence":"additional","affiliation":[{"name":"Pulmonary Diseases Unit Ospedale Infermi  Rimini Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Tinelli","sequence":"additional","affiliation":[{"name":"Biometry and Medical Statistics Unit IRCCS Policlinico San Matteo Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"De Silvestri","sequence":"additional","affiliation":[{"name":"Biometry and Medical Statistics Unit IRCCS Policlinico San Matteo Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9240-2901","authenticated-orcid":false,"given":"Valeria","family":"Scotti","sequence":"additional","affiliation":[{"name":"Scientific Documentation Service IRCCS Policlinico San Matteo Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Patelli","sequence":"additional","affiliation":[{"name":"Thoracic Endoscopy and Pulmonology Unit Maggiore Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00028706"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0998"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2007.01145.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2768"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.07.013"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.01933.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2011.02446.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.01.040"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.02.014"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00050907"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2894"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2098"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.07.103"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0b013e31829eb0b5"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2768"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.12.1083"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.1.88"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780121403"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-6-31"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1.122"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.047829"},{"key":"e_1_2_6_23_1","first-page":"229","article-title":"Ultrasound guided transbronchial needle aspiration as a diagnostic tool for lung cancer and sarcoidosis","volume":"76","author":"Szlubowski A","year":"2008","journal-title":"Pneumonol. 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