{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:21:13Z","timestamp":1773282073131,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>The 6\u2010min walk test (6MWT<\/jats:styled-content>) is a simple test assessing functional capacity, but concerns about risks of substantial oxygen desaturation in pulmonary patients have led to non\u2010adherence to the standardised A<\/jats:styled-content>merican T<\/jats:styled-content>horacic S<\/jats:styled-content>ociety guideline. We evaluated the safety of the 6MWT<\/jats:styled-content> in stable COPD<\/jats:styled-content> patients and compared the incidence of adverse events in patients with and without substantial exertional hypoxaemia.<\/jats:p><\/jats:sec>Methods<\/jats:title>6MWT<\/jats:styled-content> data were obtained for 1136 patients with moderate to very severe COPD<\/jats:styled-content>. Demographics, adverse events, oxygen saturation (SpO2<\/jats:sub><\/jats:roman><\/jats:styled-content>), 6\u2010min walk distance, lung function and quality of life measures were compared between patients with substantial exertional hypoxaemia (nadir SpO2<\/jats:sub><\/jats:roman><\/jats:styled-content>\u2009<\u200985%) and those without (SpO2<\/jats:sub><\/jats:roman><\/jats:styled-content>\u2009\u2265\u200985%). Comparisons were made using M<\/jats:styled-content>ann\u2013W<\/jats:styled-content>hitney U<\/jats:italic><\/jats:styled-content>\u2010test for continuous variables and F<\/jats:styled-content>isher's exact test for categorical variables.<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty\u2010five patients (2.2%) had adverse events, the most common being dizziness, chest tightness, chest pain and palpitations. Substantial exertional hypoxaemia did not increase the incidence of adverse events. No significant morbidity or mortality was recorded. Patients with adverse events had lower baseline SpO2<\/jats:sub><\/jats:roman><\/jats:styled-content>, worse quality of life scores, and higher depression and anxiety scores. However, no significant differences were seen in anthropometric data, spirometric values or SpO2<\/jats:sub><\/jats:roman><\/jats:styled-content> during and after the 6MWT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Asymptomatic exertional hypoxaemia is not associated with an increased incidence of adverse events during 6MWT<\/jats:styled-content> in COPD<\/jats:styled-content> patients. Our data support the ATS<\/jats:styled-content> guideline that the 6MWT<\/jats:styled-content> should be continued in the absence of symptoms and that intermittent oximetry monitoring does not assist in preventing adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12471","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T10:11:59Z","timestamp":1421748719000},"page":"419-425","source":"Crossref","is-referenced-by-count":15,"title":["Oxygen desaturation and adverse events during 6\u2010min walk testing in patients with COPD<\/scp>"],"prefix":"10.1111","volume":"20","author":[{"given":"Mary M.","family":"Roberts","sequence":"first","affiliation":[{"name":"Respiratory Ambulatory Care Service Western Sydney Local Health District Westmead Australia"},{"name":"Ludwig Engel Centre for Respiratory Research Westmead Millennium Institute Westmead Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Gun","family":"Cho","sequence":"additional","affiliation":[{"name":"Respiratory Ambulatory Care Service Western Sydney Local Health District Westmead Australia"},{"name":"Westmead Clinical School Sydney Medical School University of Sydney Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline S.","family":"Sandoz","sequence":"additional","affiliation":[{"name":"Respiratory Ambulatory Care Service Western Sydney Local Health District Westmead Australia"},{"name":"Division of Respiratory Medicine Ottawa Hospital Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Wheatley","sequence":"additional","affiliation":[{"name":"Respiratory Ambulatory Care Service Western Sydney Local Health District Westmead Australia"},{"name":"Ludwig Engel Centre for Respiratory Research Westmead Millennium Institute Westmead Australia"},{"name":"Westmead Clinical School Sydney Medical School University of Sydney Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00034603"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200510-1677OC"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0520"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200302-219OC"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-520OC"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00131813"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9906015"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17406470"},{"key":"e_1_2_7_11_1","first-page":"313","article-title":"The six\u2010minute walk test: a guide to assessment for lung transplantation","volume":"16","author":"Kadikar A","year":"1997","journal-title":"J. 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