{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:42:02Z","timestamp":1778946122705,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Fund Committee for Infectious Diseases of the government of Hong Kong Special Administrative Region of China","award":["CHP-02"],"award-info":[{"award-number":["CHP-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>Background and Objective<\/jats:title>In H<\/jats:styled-content>ong K<\/jats:styled-content>ong, neonatal B<\/jats:styled-content>acillus C<\/jats:styled-content>almette\u2013G<\/jats:styled-content>uerin (BCG<\/jats:styled-content>) vaccination is practiced with 99% coverage. This study was to compare the performance of T<\/jats:styled-content>\u2010S<\/jats:styled-content>pot.TB<\/jats:italic><\/jats:styled-content> and tuberculin skin test (TST<\/jats:styled-content>) in predicting tuberculosis (TB<\/jats:styled-content>) among household contacts.<\/jats:p><\/jats:sec>Methods<\/jats:title>From 1 M<\/jats:styled-content>arch 2006 to 31 J<\/jats:styled-content>uly 2010, 1049 asymptomatic household contacts of smear\u2010positive patients were simultaneously tested with T<\/jats:styled-content>\u2010S<\/jats:styled-content>pot.TB<\/jats:italic><\/jats:styled-content> and TST<\/jats:styled-content>, and then followed for up to 5 years for development of TB<\/jats:styled-content>. Attending clinicians and subjects were blinded to the results of T<\/jats:styled-content>\u2010S<\/jats:styled-content>pot.TB<\/jats:italic><\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>T<\/jats:styled-content>\u2010S<\/jats:styled-content>pot.TB<\/jats:italic><\/jats:styled-content> gave a significantly higher positive rate (32.7% vs 22.1%) and better association with exposure time than TST<\/jats:styled-content> at the 15\u2009mm cut\u2010off. Agreement between T<\/jats:styled-content>\u2010S<\/jats:styled-content>pot.TB<\/jats:italic><\/jats:styled-content> and TST<\/jats:styled-content> using cut\u2010offs of 5, 10 and 15\u2009mm were relatively poor (kappa 0.25\u20130.41) irrespective of presence or absence of BCG<\/jats:styled-content> scar. Only T<\/jats:styled-content>\u2010S<\/jats:styled-content>pot.TB<\/jats:italic><\/jats:styled-content> positivity was negatively associated with BCG<\/jats:styled-content> scar. Both T<\/jats:styled-content>\u2010S<\/jats:styled-content>pot.TB<\/jats:italic><\/jats:styled-content> (incidence rate ratio between test\u2010positive and test\u2010negative subjects, IRR<\/jats:styled-content>: 8.2) and TST<\/jats:styled-content> (IRR<\/jats:styled-content>: 4.1, 6.1 and 2.8, using cut\u2010offs of 5\u2009mm, 10\u2009mm and 15\u2009mm, respectively) helped to predict TB<\/jats:styled-content>. Using a TST<\/jats:styled-content> cut\u2010off of 15\u2009mm, 56% of future TB<\/jats:styled-content> cases and 62.5% of bacteriologically confirmed cases were missed. Lowering the TST<\/jats:styled-content> cut\u2010off to 10\u2009mm or 5\u2009mm could achieve sensitivity comparable with that of T<\/jats:styled-content>\u2010S<\/jats:styled-content>pot.TB<\/jats:italic><\/jats:styled-content>, but at the expense of lower specificities, with more positive tests (thus requiring treatment) per case of TB<\/jats:styled-content> predicted.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>T<\/jats:styled-content>\u2010S<\/jats:styled-content>pot.TB<\/jats:italic><\/jats:styled-content> outperformed TST<\/jats:styled-content> in predicting TB<\/jats:styled-content> among household contacts in a high\u2010income area with widespread BCG<\/jats:styled-content> vaccination coverage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12483","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:38:51Z","timestamp":1424219931000},"page":"496-503","source":"Crossref","is-referenced-by-count":13,"title":["T<\/scp>\u2010S<\/scp>pot.TB<\/i><\/scp> outperforms tuberculin skin test in predicting development of active tuberculosis among household contacts"],"prefix":"10.1111","volume":"20","author":[{"given":"Chi Chiu","family":"Leung","sequence":"first","affiliation":[{"name":"Tuberculosis and Chest Service Centre for Health Protection Department of Health Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing Cheong","family":"Yam","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Centre of Infection University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pak Leung","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Centre of Infection University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing Wai","family":"Yew","sequence":"additional","affiliation":[{"name":"Stanley Ho Centre for Emerging Infectious Diseases The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Kuen","family":"Chan","sequence":"additional","affiliation":[{"name":"Tuberculosis and Chest Service Centre for Health Protection Department of Health Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing Sze","family":"Law","sequence":"additional","affiliation":[{"name":"Tuberculosis and Chest Service Centre for Health Protection Department of Health Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuk Nor","family":"Lee","sequence":"additional","affiliation":[{"name":"Tuberculosis and Chest Service Centre for Health Protection Department of Health Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwok Chiu","family":"Chang","sequence":"additional","affiliation":[{"name":"Tuberculosis and Chest Service Centre for Health Protection Department of Health Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai Bun","family":"Tai","sequence":"additional","affiliation":[{"name":"Tuberculosis and Chest Service Centre for Health Protection Department of Health Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheuk Ming","family":"Tam","sequence":"additional","affiliation":[{"name":"Tuberculosis and Chest Service Centre for Health Protection Department of Health Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00120908"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Targeted tuberculin testing and treatment of latent tuberculosis infection. 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