{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:38Z","timestamp":1787016098926,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>\n \n Background and objective<\/jats:title>\n \n Hiatal hernias (\n HH<\/jats:styled-content>\n ) are associated with gastro\u2010oesophageal reflux and may contribute to lung disease severity. We aimed to evaluate the prevalence of\n HH<\/jats:styled-content>\n among stable non\u2010cystic fibrosis bronchiectasis (\n NCFB<\/jats:styled-content>\n ) patients and determine associations with disease severity.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A retrospective cross\u2010sectional cohort study of 100 consecutive\n NCFB<\/jats:styled-content>\n patients in our institution was performed. Data were collected on baseline variables, microbiology, lung function and radiology, according to the modified\n B<\/jats:styled-content>\n halla score. Disease severity was assessed using the\n B<\/jats:styled-content>\n ronchiectasis\n S<\/jats:styled-content>\n everity\n I<\/jats:styled-content>\n ndex (\n BSI<\/jats:styled-content>\n ) and\n FACED<\/jats:styled-content>\n severity scores.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Following expert radiological review, 81 patients were deemed suitable for study inclusion (mean age (\n SD<\/jats:styled-content>\n ) 62.6 (12.4), females 55 (67.9%), body mass index (\n BMI<\/jats:styled-content>\n ) 26.9 (5.7)); 29 (35.8%) were\n HH<\/jats:styled-content>\n positive (\n HH<\/jats:styled-content>\n +).\n HH<\/jats:styled-content>\n + patients had a trend towards higher\n BMI<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009=\u20090.07), and a significantly higher proportion had reflux symptoms (\n HH<\/jats:styled-content>\n + 62.1% vs\n HH<\/jats:styled-content>\n \u2212 28.8%,\n P<\/jats:italic>\n \u2009<\u20090.01). The presence of\n HH<\/jats:styled-content>\n + was associated with cystic bronchiectasis (\n HH<\/jats:styled-content>\n + 30.1%,\n HH<\/jats:styled-content>\n \u2212 11.5%;\n P<\/jats:italic>\n \u2009=\u20090.03), increased number of lobes involved (\n HH<\/jats:styled-content>\n + 2.62 (1.54),\n HH<\/jats:styled-content>\n \u2212 2.17 (1.42);\n P<\/jats:italic>\n \u2009=\u20090.03), increased extent of bronchiectasis, (\n HH<\/jats:styled-content>\n + 6.2 (4.7),\n HH<\/jats:styled-content>\n \u2212 4.5 (3.1);\n P<\/jats:italic>\n \u2009=\u20090.04), decreased parenchymal attenuation (\n HH<\/jats:styled-content>\n + 1.0 (1.8),\n HH<\/jats:styled-content>\n \u2212 0.2 (0.5);\n P<\/jats:italic>\n \u2009=\u20090.03) and reduced per\u2009cent predicted forced expiratory volume in 1\u2009s (\n HH<\/jats:styled-content>\n + 75.4% (24.5),\n HH<\/jats:styled-content>\n \u2212 90.4% (25.5);\n P<\/jats:italic>\n \u2009=\u20090.02). There was no lobar predilection.\n HH<\/jats:styled-content>\n + was associated with increased disease severity scores:\n BSI<\/jats:styled-content>\n (\n HH<\/jats:styled-content>\n + 4.93 (1.65),\n HH<\/jats:styled-content>\n \u2212 3.25 (2.13);\n P<\/jats:italic>\n \u2009<\u20090.001) and\n FACED<\/jats:styled-content>\n (\n HH<\/jats:styled-content>\n + 2.21 (1.52),\n HH<\/jats:styled-content>\n \u2212 1.35 (1.43);\n P<\/jats:italic>\n \u2009<\u20090.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n HH<\/jats:styled-content>\n + was associated with worse disease severity in\n NCFB<\/jats:styled-content>\n patients, characterized by decreased lung function, increased extent and severity of radiological disease, and increased composite disease severity scores.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.12522","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T20:44:54Z","timestamp":1429044294000},"page":"749-757","source":"Crossref","is-referenced-by-count":39,"title":["Hiatal hernias are correlated with increased severity of non\u2010cystic fibrosis bronchiectasis"],"prefix":"10.1111","volume":"20","author":[{"given":"Melissa Jane","family":"McDonnell","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Galway University Hospitals Galway Ireland"},{"name":"Institute of Cell and Molecular Biosciences Framlington Place Newcastle Medical School Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Galway University Hospitals Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeeban","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Radiology Galway University Hospitals Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Ward","sequence":"additional","affiliation":[{"name":"Institute of Cell and Molecular Biosciences Framlington Place Newcastle Medical School Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matshediso","family":"Mokoka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Galway University Hospitals Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Breen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Galway University Hospitals Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"O'Regan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Galway University Hospitals Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Gilmartin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Galway University Hospitals Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bruzzi","sequence":"additional","affiliation":[{"name":"Department of Radiology Galway University Hospitals Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Galway University Hospitals Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0411CI"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200904-0625OC"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-012-0261-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00101212"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00064807"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/395020"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.14613459"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.04.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62171-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2011.5.3.267"},{"key":"e_1_2_7_12_1","first-page":"215","article-title":"Hiatal hernia in asthmatic patients: prevalence and its association with gastroesophageal reflux]","volume":"51","author":"Carmona\u2010Sanchez R","year":"1999","journal-title":"Rev. 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