{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:00Z","timestamp":1787016120439,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1038124"],"award-info":[{"award-number":["1038124"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>\n \n Background and objective<\/jats:title>\n \n This study aimed to evaluate the involvement of airway cross\u2010sectional area and shape, and functional residual capacity (\n FRC<\/jats:styled-content>\n ), in the genesis of obstructive sleep apnoea (\n OSA<\/jats:styled-content>\n ) in patients with supine\u2010predominant\n OSA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Three groups were recruited: (i) supine\n OSA<\/jats:styled-content>\n , defined as a supine apnoea\u2013hyponoea index (\n AHI<\/jats:styled-content>\n ) at least twice that of the non\u2010supine\n AHI<\/jats:styled-content>\n ; (ii) rapid eye movement (\n REM<\/jats:styled-content>\n )\n OSA<\/jats:styled-content>\n , defined as\n REM AHI<\/jats:styled-content>\n at least twice the non\u2010\n REM AHI<\/jats:styled-content>\n and also selected to have supine\n AHI<\/jats:styled-content>\n less than twice that of the non\u2010supine\n AHI<\/jats:styled-content>\n (i.e. to be non\u2010positional); and (iii) no\n OSA<\/jats:styled-content>\n , defined as an\n AHI<\/jats:styled-content>\n less than five events per hour. The groups were matched for age, gender and body mass index. Patients underwent four\u2010dimensional computed tomography scanning of the upper airway in the supine and lateral decubitus positions.\n FRC<\/jats:styled-content>\n was measured in the seated, supine and lateral decubitus positions.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients with supine\n OSA<\/jats:styled-content>\n demonstrated a significant decrease in\n FRC<\/jats:styled-content>\n of 340\u2009mL (\n P<\/jats:italic>\n \u2009=\u20090.026) when moving from the lateral to supine position compared to controls with no\n OSA<\/jats:styled-content>\n , and\n REM OSA<\/jats:styled-content>\n patients. We found no differences between groups in upper airway size and shape. However, all groups showed a significant change in airway shape with the velopharyngeal airway adopting a more elliptoid shape (with the long axis laterally oriented), with reduced anteroposterior diameter in the supine position.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n A fall in\n FRC<\/jats:styled-content>\n when moving lateral to supine in supine\n OSA<\/jats:styled-content>\n patients may be an important triggering factor in the generation of\n OSA<\/jats:styled-content>\n in this patient group.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.12549","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T08:41:11Z","timestamp":1430728871000},"page":"819-827","source":"Crossref","is-referenced-by-count":45,"title":["Evaluation of the role of lung volume and airway size and shape in supine\u2010predominant obstructive sleep apnoea patients"],"prefix":"10.1111","volume":"20","author":[{"given":"Simon A.","family":"Joosten","sequence":"first","affiliation":[{"name":"Monash Lung and Sleep Monash Health Monash Medical Centre Melbourne Australia"},{"name":"Ritchie Centre Monash Institute of Medical Research Monash University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Sands","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Physiology and School of Psychological Sciences Monash University Melbourne Australia"},{"name":"Division of Sleep Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kais","family":"Hamza","sequence":"additional","affiliation":[{"name":"School of Mathematical Sciences Monash University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Turton","sequence":"additional","affiliation":[{"name":"Monash Lung and Sleep Monash Health Monash Medical Centre Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth K.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging Monash Health Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Crossett","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging Monash Health Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Berger","sequence":"additional","affiliation":[{"name":"Ritchie Centre Monash Institute of Medical Research Monash University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garun 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