{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:54:51Z","timestamp":1770220491228,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cooperative Research Centre for Asthma and Airways","award":["CRCAA_2.1"],"award-info":[{"award-number":["CRCAA_2.1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Small airway dysfunction is associated with asthma severity and control, but its association with airway inflammation is unknown. The aim was to determine the association between sputum inflammatory cells and the site of small airway dysfunction, measured by multiple breath nitrogen washout in convection\u2010dependent (Scond) and more peripheral diffusion\u2010dependent (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>acin) airways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010three (20\u201367 years) subjects with asthma on inhaled corticosteroid (<jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content>) treatment were characterized by spirometry, Scond, Sacin and induced sputum differential counts. %Predicted values for Scond and Sacin were calculated from published reference equations to adjust for the effects of age. Univariate correlations were assessed using the Spearman test. Multivariate linear regressions were performed to account for potential confounders, including age, gender, disease duration, body mass index and <jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content> dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sacin (%predicted) correlated significantly with neutrophil% (r<jats:sub>s<\/jats:sub>\u2009=\u20090.33, <jats:italic>P<\/jats:italic>\u2009=\u20090.02), <jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content> dose (r<jats:sub>s<\/jats:sub>\u2009=\u2009\u22120.28, <jats:italic>P<\/jats:italic>\u2009=\u20090.04) and age (r<jats:sub>s<\/jats:sub>\u2009=\u20090.27, <jats:italic>P<\/jats:italic>\u2009=\u20090.05). In multivariate analysis, Sacin related only to neutrophil% (adjusted R<jats:sup>2<\/jats:sup>\u2009=\u20090.18, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). Scond (%predicted) correlated significantly only with eosinophil% (r<jats:sub>s<\/jats:sub>\u2009=\u20090.39, <jats:italic>P<\/jats:italic>\u2009=\u20090.004). There was a trend for a negative relationship with <jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content> dose (r<jats:sub>s<\/jats:sub>\u2009=\u2009\u22120.26, <jats:italic>P<\/jats:italic>\u2009=\u20090.06). In multivariate analysis, Scond related to eosinophil% and <jats:styled-content style=\"fixed-case\">ICS<\/jats:styled-content> dose independently (adjusted R<jats:sup>2<\/jats:sup>\u2009=\u20090.12, <jats:italic>P<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acinar and conductive airway dysfunction is associated with different inflammatory profiles in asthmatic airways, independently of the effects of age and disease duration. The association between acinar airway dysfunction and neutrophilic airway inflammation may have implications for asthma treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12550","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T08:24:54Z","timestamp":1430987094000},"page":"975-981","source":"Crossref","is-referenced-by-count":27,"title":["Association between peripheral airway function and neutrophilic inflammation in asthma"],"prefix":"10.1111","volume":"20","author":[{"given":"Claude S.","family":"Farah","sequence":"first","affiliation":[{"name":"Physiology and Imaging Group The Woolcock Institute of Medical Research  Glebe Australia"},{"name":"Sydney Medical School The University of Sydney  Concord Australia"},{"name":"Department of Respiratory Medicine Concord Hospital  Concord Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurien A.B.","family":"Keulers","sequence":"additional","affiliation":[{"name":"University of Groningen University Medical Center Groningen Department of Pulmonology GRIAC Research Institute  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate M.","family":"Hardaker","sequence":"additional","affiliation":[{"name":"Physiology and Imaging Group The Woolcock Institute of Medical Research  Glebe Australia"},{"name":"Sydney Medical School The University of Sydney  Concord Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Peters","sequence":"additional","affiliation":[{"name":"Sydney Medical School The University of Sydney  Concord Australia"},{"name":"Department of Respiratory Medicine Concord Hospital  Concord Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Berend","sequence":"additional","affiliation":[{"name":"Physiology and Imaging Group The Woolcock Institute of Medical Research  Glebe Australia"},{"name":"Sydney Medical School The University of Sydney  Concord Australia"},{"name":"Respiratory Research Group The George Institute for Global Health  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirkje S.","family":"Postma","sequence":"additional","affiliation":[{"name":"University of Groningen University Medical Center Groningen Department of Pulmonology GRIAC Research Institute  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl M.","family":"Salome","sequence":"additional","affiliation":[{"name":"Physiology and Imaging Group The Woolcock Institute of Medical Research  Glebe Australia"},{"name":"Sydney Medical School The University of Sydney  Concord Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory G.","family":"King","sequence":"additional","affiliation":[{"name":"Physiology and Imaging Group The Woolcock Institute of Medical Research  Glebe Australia"},{"name":"Sydney Medical School The University of Sydney  Concord Australia"},{"name":"Department of Respiratory Medicine Royal North Shore Hospital  St Leonards New South Wales 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