{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:05:42Z","timestamp":1773723942833,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T00:00:00Z","timestamp":1432166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>\n \n Background and objective<\/jats:title>\n \n Obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease (\n COPD<\/jats:styled-content>\n ), have airflow limitation associated with chronic inflammation. Using a national inpatient database in\n J<\/jats:styled-content>\n apan, we aimed to evaluate factors affecting in\u2010hospital mortality in patients with asthma,\n COPD<\/jats:styled-content>\n or asthma\u2013\n COPD<\/jats:styled-content>\n overlap (\n ACO<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We retrospectively collected data for inpatients (age >40 years) with exacerbation of\n COPD<\/jats:styled-content>\n and\/or asthma in 1073 hospitals across\n J<\/jats:styled-content>\n apan between\n J<\/jats:styled-content>\n uly 2010 and\n M<\/jats:styled-content>\n ay 2013. We performed multivariable logistic regression analysis to examine the association of various factors with all\u2010cause in\u2010hospital mortality, including diagnosis of\n ACO<\/jats:styled-content>\n , asthma alone and\n COPD<\/jats:styled-content>\n alone.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 30\u2009405 eligible patients, in\u2010hospital mortality in patients with\n ACO<\/jats:styled-content>\n , asthma alone and\n COPD<\/jats:styled-content>\n alone was 2.3%, 1.2% and 9.7%, respectively.\n COPD<\/jats:styled-content>\n patients had a significantly higher mortality than\n ACO<\/jats:styled-content>\n patients (odds ratio 1.96; 95% confidence interval: 1.38\u20132.79); patients with asthma alone showed lower mortality (0.70; 0.50\u20130.97). Higher mortality was also significantly associated with older age, male gender, lower body mass index, more severe dyspnoea, lower level of consciousness, worse activities of daily life and higher daily dose of corticosteroids.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Asthma alone was associated with lower mortality, but\n COPD<\/jats:styled-content>\n alone was associated with higher mortality than\n ACO<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/resp.12556","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T05:59:48Z","timestamp":1432187988000},"page":"940-946","source":"Crossref","is-referenced-by-count":52,"title":["Comparison of in\u2010hospital mortality in patients with\n COPD<\/scp>\n , asthma and asthma\u2013\n COPD<\/scp>\n overlap exacerbations"],"prefix":"10.1111","volume":"20","author":[{"given":"Yasuhiro","family":"Yamauchi","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan"},{"name":"Division for Health Service Promotion The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics School of Public Health The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics School of Public Health The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wakae","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisuke","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan"},{"name":"Division for Health Service Promotion The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Takami","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohide","family":"Fushimi","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Informatics Tokyo Medical and Dental University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahide","family":"Nagase","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,21]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Global Initiative for Asthma.GINA Report Global strategy for asthma management and prevention. Updated May 2014.2014. [Accessed 23 Nov 2014.] Available from URL:www.ginasthma.org\/local\/uploads\/files\/GINA_Report_2014_Aug12.pdf"},{"key":"e_1_2_7_3_1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease.GOLD: global strategy for diagnosis management and prevention of COPD. Updated January 2014.2014. [Accessed 23 Nov 2014.] Available from URL:www.goldcopd.org\/Guidelines\/guidelines\u2010resources.html"},{"key":"e_1_2_7_4_1","unstructured":"Global Initiative for Asthma and Global Initiative for Chronic Obstructive Lung Disease.Asthma COPD and asthma\u2010COPD overlap syndrome. Updated May 2014.2014. 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Dis."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-127"},{"key":"e_1_2_7_10_1","first-page":"7","article-title":"Overlap of asthma and chronic obstructive pulmonary disease","volume":"11","author":"Guerra S","year":"2005","journal-title":"Curr. Opin. Pulm. Med."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.108027"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4749.65"},{"key":"e_1_2_7_13_1","first-page":"623","article-title":"[New grading of level of disordered consciousness (author's transl)]","volume":"2","author":"Ohta T","year":"1974","journal-title":"No Shinkei Geka"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.74.1.0081"},{"key":"e_1_2_7_15_1","first-page":"61","article-title":"Functional evaluation: the Barthel index","volume":"14","author":"Mahoney FI","year":"1965","journal-title":"Md State Med. 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