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The increased mechanical load in obese individuals leads to reduced chest wall and lung compliance and increased work of breathing. While there is generally minimal effect on spirometric values, as body mass index increases, the expiratory reserve volume, and hence functional residual capacity, reduces, often approaching residual volume in more severe obesity. The majority of evidence however suggests that obese individuals free from lung disease have relatively normal gas exchange. The link between asthma and obesity, while initially unclear, is now recognized as being a distinct asthma phenotype. While studies investigating objective markers of asthma have shown that there is no association between obesity and airway hyper\u2010responsiveness, a recent working group identified obesity as a major risk factor for the development of asthma in all demographic groups.<\/jats:p><jats:p>Although the temptation may be to attribute obesity as the cause of dyspnoea in symptomatic obese patients, accurate respiratory assessment of these individuals is necessary. Lung function tests can confirm that any altered physiology are the known respiratory consequences of obesity. However, given that obesity causes minimal changes in lung function, significant abnormalities warrant further investigation. An important consideration is the knowledge that many of the respiratory physiology consequences of obesity are reversible by weight loss.<\/jats:p>","DOI":"10.1111\/resp.12563","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T15:00:28Z","timestamp":1433257228000},"page":"715-721","source":"Crossref","is-referenced-by-count":67,"title":["Optimizing respiratory function assessments to elucidate the impact of obesity on respiratory health"],"prefix":"10.1111","volume":"20","author":[{"given":"Danny J.","family":"Brazzale","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Austin Hospital  Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep Austin Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Pretto","sequence":"additional","affiliation":[{"name":"Institute for Breathing and Sleep Austin Hospital  Melbourne Victoria Australia"},{"name":"Department of Respiratory and Sleep Medicine John Hunter Hospital  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M.","family":"Schachter","sequence":"additional","affiliation":[{"name":"Centre for Obesity Research and Education Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organisation.Obesity and overweight fact sheet number 311.2014. 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