{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:09:10Z","timestamp":1762506550737},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>There is relatively little data regarding pulmonary function test (PFT<\/jats:styled-content>) findings and impact of treatment on PFT<\/jats:styled-content> in pulmonary nontuberculous mycobacterial (pNTM<\/jats:styled-content>) disease.<\/jats:p><\/jats:sec>Methods<\/jats:title>We performed a retrospective study on pNTM<\/jats:styled-content> patients. Clinical, radiographical, microbiological and PFT<\/jats:styled-content> data were reviewed. Patients were divided into three groups based on pre\u2010existing obstructive lung disease: (i) normal (no chronic obstructive pulmonary disease (COPD) or asthma); (ii) asthma; and (iii) COPD<\/jats:styled-content>. We studied pre\u2010treatment PFT<\/jats:styled-content> and assessed for PFT<\/jats:styled-content> changes after anti\u2010mycobacterial therapy.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 96 patients fulfilled ATS<\/jats:styled-content> disease criteria and had pre\u2010treatment PFT<\/jats:styled-content> (54 \u2018normal\u2019, 18 asthma, 24 COPD<\/jats:styled-content>). Most common causative NTM<\/jats:styled-content> was M<\/jats:italic><\/jats:styled-content>ycobacterium avium<\/jats:italic> complex (76%), and radiographical disease type was nodular bronchiectasis (71%). Before therapy, all groups had PFT<\/jats:styled-content> abnormalities, including obstruction, gas trapping and at least mildly low diffusion capacity of carbon monoxide (DLCO). Pre\u2010treatment PFT abnormalities were more pronounced among patients with asthma and COPD<\/jats:styled-content>. A total of 44 patients had >12 months anti\u2010mycobacterial therapy and post\u2010treatment PFT<\/jats:styled-content>. There tended to be small and generally not statistically significant reductions in spirometry and DLCO in most groups. Among the nine asthmatic patients, there was a small reduction in residual volume (RV) (1.5% predicted, P<\/jats:italic>\u2009=\u20090.01) and RV\/total lung capacity (by 7% predicted, P<\/jats:italic>\u2009=\u20090.06).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Patients with pNTM<\/jats:styled-content> have abnormal PFT<\/jats:styled-content>, and treatment was not associated with substantial changes therein. Asthmatics may experience some improvements in gas trapping after NTM<\/jats:styled-content> therapy, but because the sample size and the observed change were both small, this requires further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12565","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T14:59:40Z","timestamp":1432565980000},"page":"987-993","source":"Crossref","is-referenced-by-count":11,"title":["Impact of pulmonary nontuberculous mycobacterial treatment on pulmonary function tests in patients with and without established obstructive lung disease"],"prefix":"10.1111","volume":"20","author":[{"given":"Mauli","family":"Mehta","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Schulich School of Medicine and Dentistry \u2013 Western University London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth R.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Joint Division of Respirology University Health Network and Mount Sinai Hospital Department of Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Heffer","sequence":"additional","affiliation":[{"name":"Division of Respirology and Medicine St. Joseph's Health Centre Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore K.","family":"Marras","sequence":"additional","affiliation":[{"name":"Joint Division of Respirology University Health Network and Mount Sinai Hospital Department of Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201002-0310OC"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.070797"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201003-0503OC"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.4.1033"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058214"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322011000400005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr503"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.11.0412"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1403.061405"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000029462"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(57)90025-6"},{"key":"e_1_2_6_14_1","first-page":"769","article-title":"The role of tuberculosis and other forms of bronchopulmonary necrosis in the pathogenesis of bronchiectasis","volume":"93","author":"Rosenzweig DY","year":"1966","journal-title":"Am. 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