{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:24:56Z","timestamp":1792110296971,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinical Research Priority Program (CRPP) Sleep and Health of the University of Zurich"},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["SNF_32003B_143365"],"award-info":[{"award-number":["SNF_32003B_143365"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Obstructive sleep apnoea (\n                    <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                    ) is a prevalent sleep\u2010related breathing disorder associated with adverse cardiovascular outcome. Endothelial dysfunction is one of the proposed mechanistic links between\n                    <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                    and the increased cardiovascular risk. Treatment with continuous positive airway pressure (\n                    <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>\n                    ) may reverse this detrimental pathophysiological consequence of\n                    <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                    . Most studies on the effect of\n                    <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>\n                    on endothelial function in\n                    <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                    are limited by their low sample size. The objective of this systematic review was to assess the effect\n                    <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>\n                    therapy on endothelial function in patients with\n                    <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                    . We conducted a systematic review and meta\u2010analysis searching literature databases up to\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    ugust 2013 for randomized controlled trials (\n                    <jats:styled-content style=\"fixed-case\">RCTs<\/jats:styled-content>\n                    ) on the effect of\n                    <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>\n                    on endothelial function in\n                    <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                    , assessed by flow\u2010mediated dilatation (\n                    <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>\n                    ) and other validated techniques. The primary outcome for the meta\u2010analysis (DerSimonian\/Laird random\u2010effects method) was the treatment effect on\n                    <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>\n                    . Eight\n                    <jats:styled-content style=\"fixed-case\">RCTs<\/jats:styled-content>\n                    comparing the effects of therapeutic\n                    <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>\n                    versus subtherapeutic\n                    <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>\n                    (or no intervention) on endothelial function involving 245\n                    <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                    patients were included in the systematic review. The studies are consistent in effect direction, showing an improvement of endothelial function by\n                    <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>\n                    . Four\n                    <jats:styled-content style=\"fixed-case\">RCTs<\/jats:styled-content>\n                    involving 150 patients could be used for the meta\u2010analysis. Compared to the control group,\n                    <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>\n                    therapy (range 2\u201324 weeks) significantly increased absolute %\n                    <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>\n                    by 3.87% (95% confidence interval: 1.93\u20135.80,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). In patients with\n                    <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>\n                    therapy improves endothelial function significantly and to a clinically important extent.\n                  <\/jats:p>","DOI":"10.1111\/resp.12573","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T04:55:26Z","timestamp":1434344126000},"page":"889-895","source":"Crossref","is-referenced-by-count":134,"title":["Effect of\n                    <scp>CPAP<\/scp>\n                    therapy on endothelial function in obstructive sleep apnoea: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"20","author":[{"given":"Esther I","family":"Schwarz","sequence":"first","affiliation":[{"name":"Sleep Disorders Center and Pulmonary Division University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo A","family":"Puhan","sequence":"additional","affiliation":[{"name":"Institute for Social and Preventive Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schlatzer","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center and Pulmonary Division University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Stradling","sequence":"additional","affiliation":[{"name":"Oxford Centre for Respiratory Medicine and Oxford Biomedical Research Centre Churchill Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Kohler","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center and Pulmonary Division University Hospital of Zurich  Zurich Switzerland"},{"name":"Center for Integrative Human Physiology University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.1.2001008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.04.026"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.145"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022287"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000012543.55874.47"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.2.191"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp053"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.06.013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.30.669"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200306-767OC"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.21.2607"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200306-756OC"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01746-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93147-F"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1741826711398179"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/31\/1\/001"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365519609090591"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2466"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-11-201006010-00232"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00131-0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-008-9115-5"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.081877"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-0179"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-12-50"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201106-0964OC"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.100537"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.01.166"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2105124"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2741\/e469"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.741512"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq340"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960281004"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00327-4"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.16.1899"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000025404.78001.D8"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.01.021"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095273.92468.D9"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00333-4"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00927-6"},{"key":"e_1_2_8_43_1","first-page":"138","article-title":"The 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