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In the diagnostic approach to <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>, a diagnosis of <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> should be considered particularly in women and subjects younger than 50 years, and in those with an imaging and\/or pathological pattern of non\u2010specific interstitial pneumonia. However, the diagnosis of <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> may be difficult when <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> is the presenting or the dominant manifestation of <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>. A proportion of patients with <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> present symptoms that belong to the spectrum of <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> and\/or biological autoimmune features, but do not fulfil diagnostic criteria for a given <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>. Some imaging and histopathological patterns may also suggest the presence of an underlying <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>. Although studies published to date used heterogeneous definitions and terminology for this condition, evidence is accumulating that even limited <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> features are relevant regarding symptoms, imaging features, pathological pattern and possibly evolution to overt <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>, whereas the impact on prognosis needs confirmation. Conversely, autoantibodies alone do not seem to impact the prognosis or management in patients with otherwise typical idiopathic pulmonary fibrosis and no extra\u2010pulmonary manifestation. A collective international multidisciplinary effort has proposed a uniform definition and criteria for \u2018interstitial pneumonia with autoimmune features\u2019, a condition characterized by limited <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> features occurring in the setting of <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>, with the aim of fostering future clinical studies. Referral of <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> patients suspect to have <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> to a rheumatologist and possibly multidisciplinary discussion may contribute to a better management.<\/jats:p>","DOI":"10.1111\/resp.12588","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T02:25:26Z","timestamp":1437963926000},"page":"245-258","source":"Crossref","is-referenced-by-count":72,"title":["Idiopathic interstitial pneumonias with connective tissue diseases features: A review"],"prefix":"10.1111","volume":"21","author":[{"given":"Vincent","family":"Cottin","sequence":"first","affiliation":[{"name":"National Reference Center for Rare Pulmonary Diseases Lyon University Hospitals  Lyon France"},{"name":"Department of Respiratory Medicine Louis Pradel Hospital  Lyon France"},{"name":"Claude Bernard Lyon 1 University  Lyon France"},{"name":"University of Lyon; INRA  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61079-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2012.01.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-2401-6_25"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-2401-6_26"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200607-912OC"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.08.015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq233"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-2401-6_27"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1183\/09031936.93.02010007","article-title":"Subclinical alveolar inflammation in rheumatoid arthritis: superoxide anion, neutrophil chemotactic activity and fibronectin generation by alveolar macrophages","volume":"2","author":"Perez T","year":"1989","journal-title":"Eur. 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