{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:56:01Z","timestamp":1787165761124,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>A handful of studies have reported that bronchoscopies influence the clinical outcome of mechanically ventilated patients with aspiration pneumonia. The purpose of the present study is to elucidate the therapeutic role of early bronchoscopy in patients with aspiration who are mechanically ventilated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted via medical record review from 2003 through 2013 in a tertiary hospital. All the diagnoses of pneumonia were supported by the probability of aspiration and consolidation of dependent areas confirmed by computed tomography. Patients who underwent bronchoscopy within 24\u2009h after intubation were categorized as the early bronchoscopy group and the others as the late bronchoscopy group. We compared the demographics, clinical parameters and outcomes between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 154 patients who were included, the early bronchoscopy group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200993) showed significantly lower in\u2010intensive care unit (\n                      <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>\n                      ) mortality and 90\u2010day mortality (in\u2010\n                      <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>\n                      : 4.9% vs 24.6%; 90\u2010day: 11.8 vs 32.8%) regardless of the initial empirical antibiotics. In addition, their sequential organ failure assessment score on day 7 tended to decrease more rapidly. Among the survivors, patients in the early bronchoscopy group were extubated earlier with a higher success rate, had a shorter length of mechanical ventilation and had a shorter\n                      <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>\n                      stay. The early bronchoscopy was associated with lower 90\u2010day mortality in multivariate analysis (odds ratio: 0.412; 95% confidence interval: 0.192\u20130.883).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early bronchoscopy could benefit the clinical outcomes of mechanically ventilated patients with aspiration pneumonia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.12590","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T05:39:10Z","timestamp":1436161150000},"page":"1115-1122","source":"Crossref","is-referenced-by-count":23,"title":["Clinical impact of early bronchoscopy in mechanically ventilated patients with aspiration pneumonia"],"prefix":"10.1111","volume":"20","author":[{"given":"Hyun Woo","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsoo","family":"Min","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisoo","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Sun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Il","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon\u2010Taek","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Jae","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam\u2010si South 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