{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:56:38Z","timestamp":1790751398671,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sociedad Espa\u00f1ola de Neumolog\u00eda (SEPAR)"},{"name":"Fundaci\u00f3 Catalana de Pneumologia (FUCAP)"},{"name":"Tenovus Scotland"},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["K23HL096054"],"award-info":[{"award-number":["K23HL096054"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>Secreted mucins play a key role in antibacterial defence in the airway, but have not previously been characterized in non\u2010cystic fibrosis (CF) bronchiectasis patients. We aim to investigate the relationship between secreted mucins levels and the presence of bacterial colonization due to potentially pathogenic microorganisms (PPM<\/jats:styled-content>) in the airways of stable bronchiectasis patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Clinically stable bronchiectasis patients were studied prospectively at two centres. Patients with other pulmonary conditions were excluded. Spontaneous sputum was subject to bacterial culture, and secreted mucins (MUC2<\/jats:styled-content>, MUC5AC<\/jats:styled-content> and MUC5B<\/jats:styled-content>) were measured in sputum supernatants by ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 50 patients were included. PPM<\/jats:styled-content> were identified from sputum samples in 30 (60%), with P<\/jats:italic><\/jats:styled-content>seudomonas aeruginosa<\/jats:italic> (n<\/jats:italic>\u2009=\u200910) and H<\/jats:italic><\/jats:styled-content>aemophilus influenzae<\/jats:italic> (n<\/jats:italic>\u2009=\u200910) as the most common PPM<\/jats:styled-content>. There were no baseline differences among airway colonized and non\u2010colonized patients. Patients with airways colonized by PPM<\/jats:styled-content> presented higher levels of airway MUC2<\/jats:styled-content>. No differences in MUC5AC<\/jats:styled-content> levels were found among groups, whereas MUC5B<\/jats:styled-content> levels were undetectable. Patients with P<\/jats:italic><\/jats:styled-content>.\u2009aeruginosa<\/jats:italic> colonization expressed the highest levels of MUC2<\/jats:styled-content>. High levels of MUC2<\/jats:styled-content> and MUC5AC<\/jats:styled-content> are also correlated with disease severity using the B<\/jats:styled-content>ronchiectasis S<\/jats:styled-content>everity I<\/jats:styled-content>ndex.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Airway MUC2<\/jats:styled-content> levels were higher in bronchiectasis patients colonized with PPM<\/jats:styled-content> compared with those without airway colonization, especially in patients with P<\/jats:italic><\/jats:styled-content>.\u2009aeruginosa<\/jats:italic>. These findings suggest that airway\u2010secreted mucins levels may play a role in the pathogenesis of airway infection in non\u2010CF bronchiectasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12595","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T18:42:31Z","timestamp":1436899351000},"page":"1082-1088","source":"Crossref","is-referenced-by-count":52,"title":["Secreted mucins and airway bacterial colonization in non\u2010CF<\/scp> bronchiectasis"],"prefix":"10.1111","volume":"20","author":[{"given":"Oriol","family":"Sibila","sequence":"first","affiliation":[{"name":"Respiratory Department Hospital de la Santa Creu i Sant Pau Universitat Autonoma de Barcelona Barcelona Spain"},{"name":"Biomedical Research Institute Sant Pau (IIB Sant Pau) Hospital de la Santa Creu i Sant Pau Universitat Autonoma de Barcelona Barcelona 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Research Group University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Finch","sequence":"additional","affiliation":[{"name":"Tayside Respiratory Research Group University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eder Freddy","family":"Mateus","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute Sant Pau (IIB Sant Pau) Hospital de la Santa Creu i Sant Pau Universitat Autonoma de Barcelona Barcelona Spain"},{"name":"Laboratory of Experimental Immunology Hospital de la Santa Creu i Sant Pau Universitat Autonoma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Garcia\u2010Bellmunt","sequence":"additional","affiliation":[{"name":"Respiratory Department Hospital de la Santa Creu i Sant Pau Universitat Autonoma de Barcelona Barcelona Spain"},{"name":"Biomedical Research Institute Sant Pau (IIB Sant Pau) Hospital de la Santa Creu i Sant Pau Universitat Autonoma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Castillo","sequence":"additional","affiliation":[{"name":"Respiratory Department Hospital de la Santa Creu i Sant Pau Universitat Autonoma de Barcelona Barcelona Spain"},{"name":"Biomedical Research Institute Sant Pau (IIB Sant Pau) Hospital de la Santa Creu i Sant Pau Universitat Autonoma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Vidal","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute Sant Pau (IIB Sant Pau) Hospital de la Santa Creu i Sant Pau Universitat Autonoma de Barcelona Barcelona Spain"},{"name":"Laboratory of Experimental Immunology Hospital de la Santa Creu i Sant Pau Universitat Autonoma de Barcelona Barcelona 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