{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:19:16Z","timestamp":1778703556515,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T00:00:00Z","timestamp":1439424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>Cold\u2010induced airway hyperresponsiveness (CAH<\/jats:styled-content>) is common in bronchial asthma (BA<\/jats:styled-content>) patients and represents a problem for those living in cold climate. Transient receptor potential melastatin 8 (TRPM<\/jats:styled-content>8) channel is the main cold temperature sensor in humans that could mediate cold response in asthmatics with CAH<\/jats:styled-content>. No associations between TRPM8<\/jats:italic><\/jats:styled-content> gene polymorphisms and CAH<\/jats:styled-content> have been reported.<\/jats:p><\/jats:sec>Methods<\/jats:title>The present study involved 123 BA<\/jats:styled-content> patients. CAH<\/jats:styled-content> was assessed by 3\u2010min isocapnic (5% CO2<\/jats:sub>) cold air (\u221220\u00b0C) hyperventilation challenge. The c.750G\u2009>\u2009C<\/jats:styled-content> (rs11562975), c.1256G\u2009>\u2009A<\/jats:styled-content> (rs7593557), c.3048C\u2009>\u2009T<\/jats:styled-content> (rs11563208) and c.3174C\u2009>\u2009G<\/jats:styled-content> (rs11563071) polymorphisms of TRPM8<\/jats:italic><\/jats:styled-content> gene were genotyped by allele\u2010specific polymerase chain reaction (PCR) and PCR with subsequent restriction fragment length polymorphism analysis.<\/jats:p><\/jats:sec>Results:<\/jats:italic><\/jats:title>GC<\/jats:styled-content> genotype and C<\/jats:styled-content> allele carriers of the c.750G\u2009>\u2009C<\/jats:styled-content> (rs11562975) polymorphism were more frequently observed to exhibit CAH<\/jats:styled-content>. The estimated odds ratio for the GC<\/jats:styled-content> genotype was 3.73 95%CI<\/jats:styled-content> (1.48; 9.37), P<\/jats:italic>\u2009=\u20090.005. Furthermore, GC<\/jats:styled-content> heterozygotes had a prominent decrease in forced expiratory volume in 1\u2009s after the challenge as compared to GG<\/jats:styled-content> homozygotes (\u221212% (\u221216; \u22128.1) vs \u22126.45% (\u221211; \u22122.1), P<\/jats:italic>\u2009<\u20090.001). GC<\/jats:styled-content> carriers also had a marked reduction in other spirometric parameters.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The GC<\/jats:styled-content> variant of the TRPM8<\/jats:italic><\/jats:styled-content>:c.750G\u2009>\u2009C<\/jats:styled-content> (rs11562975) polymorphism is associated with CAH<\/jats:styled-content> in patients with BA<\/jats:styled-content>, which suggests a potential role of TRPM8<\/jats:italic> in CAH<\/jats:styled-content> development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12605","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T04:38:58Z","timestamp":1439527138000},"page":"1192-1197","source":"Crossref","is-referenced-by-count":21,"title":["Transient receptor potential melastatin 8 gene polymorphism is associated with cold\u2010induced airway hyperresponsiveness in bronchial asthma"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3921-8755","authenticated-orcid":false,"given":"Denis E","family":"Naumov","sequence":"first","affiliation":[{"name":"Laboratory of Prophylaxis of Nonspecific Lung Diseases Far Eastern Scientific Centre of Physiology and Pathology of Respiration Blagoveshchensk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliy M","family":"Perelman","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Research of Respiratory System Far Eastern Scientific Centre of Physiology and Pathology of Respiration Blagoveshchensk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor P","family":"Kolosov","sequence":"additional","affiliation":[{"name":"Laboratory of Prophylaxis of Nonspecific Lung Diseases Far Eastern Scientific Centre of Physiology and Pathology of Respiration Blagoveshchensk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana A","family":"Potapova","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics Research Institute of Internal and Preventive Medicine Novosibirsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir N","family":"Maksimov","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics Research Institute of Internal and Preventive Medicine Novosibirsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangdong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.18093\/0869-0189-2008-0-1-69-74","article-title":"The particularities of cold induced bronchial hyperreactivity in patients with chronic respiratory diseases","volume":"1","author":"Prikhodko AG","year":"2008","journal-title":"Pulmonology"},{"key":"e_1_2_7_3_1","first-page":"53","article-title":"Values of bronchial asthma control in patients with cold\u2010induced bronchial hyperreactivity","volume":"3","author":"Kolosov VP","year":"2010","journal-title":"Pulmonology"},{"key":"e_1_2_7_4_1","first-page":"29","article-title":"Seasonal peculiarities of life quality in patients with bronchial asthma and cold airway hyperresponsiveness","volume":"31","author":"Perelman NL","year":"2009","journal-title":"Bull. 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