{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:37:58Z","timestamp":1761964678208},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>Studies have shown that patients with acute eosinophilic pneumonia (AEP<\/jats:styled-content>) and with initial eosinophilia have a milder disease than those with an initial normal peripheral eosinophil count (PEC<\/jats:styled-content>). We investigated the effect of a rapid corticosteroid tapering strategy in AEP<\/jats:styled-content> patients with initial eosinophilia.<\/jats:p><\/jats:sec>Methods<\/jats:title>We performed a prospective cohort study in patients with AEP<\/jats:styled-content> with initial eosinophilia (n<\/jats:italic>\u2009=\u200914) who stopped corticosteroid treatment after achieving clinical stabilization compared with AEP<\/jats:styled-content> patients with an initial normal PEC<\/jats:styled-content> (n<\/jats:italic>\u2009=\u200945) who received 2\u2010week treatment with corticosteroid.<\/jats:p><\/jats:sec>Results<\/jats:title>In total, 59 AEP<\/jats:styled-content> patients were identified. The median duration of corticosteroid treatment was 4 days (interquartile ranges (IQR<\/jats:styled-content>), 3\u20134) in patients with initial eosinophilia and 14 (IQR<\/jats:styled-content>, 14\u201314) days in patients with initial normal PEC<\/jats:styled-content>. No treatment failure occurred in the group with initial eosinophilia; one treatment failure case occurred in the group with an initially normal PEC<\/jats:styled-content>. The median time to overall clinical stabilization was 3 days, and time to complete resolution of all symptoms and clinical instabilities from diagnosis was 4 days in AEP<\/jats:styled-content> patients with initial eosinophilia. Both were significantly shorter than those) in the initially normal PEC<\/jats:styled-content> group, which were 5 and 7 days respectively (both P<\/jats:italic>\u2009<\u20090.001). Adverse effects were lower in AEP<\/jats:styled-content> patients with initial eosinophilia, and additional medications to relieve adverse effects were only needed in AEP<\/jats:styled-content> patients with initially normal PEC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Rapid corticosteroid tapering may be an acceptable treatment strategy for managing AEP<\/jats:styled-content> patients with initial eosinophilia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12639","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T20:43:20Z","timestamp":1441226600000},"page":"1241-1247","source":"Crossref","is-referenced-by-count":27,"title":["Outcomes of rapid corticosteroid tapering in acute eosinophilic pneumonia patients with initial eosinophilia"],"prefix":"10.1111","volume":"20","author":[{"given":"Byung Woo","family":"Jhun","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine The Armed Forces Capital Hospital Seong\u2010nam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine The Armed Forces Capital Hospital Seong\u2010nam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine The Armed Forces Capital Hospital Seong\u2010nam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine The Armed Forces Capital Hospital Seong\u2010nam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908313210903"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.1.249"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2112056"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.24.2997"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00221811"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.12.0555"},{"key":"e_1_2_7_8_1","first-page":"92","article-title":"Cocaine\u2010induced fatal acute eosinophilic pneumonia: a case report","volume":"106","author":"McCormick 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