{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:15:25Z","timestamp":1790381725032,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>It is difficult to verify the bacteriological diagnosis of <jats:styled-content style=\"fixed-case\"><jats:italic>M<\/jats:italic><\/jats:styled-content><jats:italic>ycobacterium avium<\/jats:italic> complex (<jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content>) infection. The anti\u2010glycopeptidolipid (<jats:styled-content style=\"fixed-case\">GPL<\/jats:styled-content>)\u2010core <jats:styled-content style=\"fixed-case\">IgA<\/jats:styled-content> antibody test was recently developed as a diagnostic method for <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> pulmonary disease. Only a few studies evaluate its clinical efficacy. We conducted retrospective evaluations of clinical characteristics of patients suspected of <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> infection to explore the usefulness of the anti\u2010<jats:styled-content style=\"fixed-case\">GPL<\/jats:styled-content>\u2010core <jats:styled-content style=\"fixed-case\">IgA<\/jats:styled-content> antibody test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated 296 patients who were suspected to have <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> infection and underwent anti\u2010<jats:styled-content style=\"fixed-case\">GPL<\/jats:styled-content>\u2010core <jats:styled-content style=\"fixed-case\">IgA<\/jats:styled-content> antibody test between <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2013 and <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2014 in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>ikei <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 29 patients were diagnosed with \u2018definite <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content>\u2019 based on the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merican <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>horacic <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ociety (<jats:styled-content style=\"fixed-case\">ATS<\/jats:styled-content>) criteria with multiple identifications of <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content>. On the other hand, 106 patients were diagnosed with other pulmonary diseases than <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content>. The sensitivity and specificity of anti\u2010<jats:styled-content style=\"fixed-case\">GPL<\/jats:styled-content>\u2010core <jats:styled-content style=\"fixed-case\">IgA<\/jats:styled-content> antibody test for <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> diagnosis were 58.6% and 98.1%, respectively. The definite <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> group showed no significant differences in strains, treatment history or number of segments involved. The duration of <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> disease in the positive\u2010antibody group was significantly longer than in the negative\u2010antibody group (<jats:italic>P<\/jats:italic>\u2009=\u20090.046). A significant increase in the false\u2010negative rate was observed in patients with malignant disease (<jats:italic>P<\/jats:italic>\u2009=\u20090.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The anti\u2010<jats:styled-content style=\"fixed-case\">GPL<\/jats:styled-content>\u2010core <jats:styled-content style=\"fixed-case\">IgA<\/jats:styled-content> antibody test demonstrated high sensitivity and specificity for the diagnosis of <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> infection especially in patients without malignant diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12640","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T08:13:53Z","timestamp":1441354433000},"page":"1277-1281","source":"Crossref","is-referenced-by-count":16,"title":["Clinical efficacy of anti\u2010glycopeptidolipid\u2010core <scp>IgA<\/scp> test for diagnosing <scp><i>M<\/i><\/scp><i>ycobacterium avium<\/i> complex infection in lung"],"prefix":"10.1111","volume":"20","author":[{"given":"Takanori","family":"Numata","sequence":"first","affiliation":[{"name":"Division of Respiratory Diseases Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Araya","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Yoshii","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Hara","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"e_1_2_6_3_1","first-page":"25","article-title":"The non\u2010tuberculous mycobacteriosis","volume":"80","author":"Sakatani M","year":"2005","journal-title":"Kekkaku"},{"key":"e_1_2_6_4_1","first-page":"44","article-title":"Use of glycopeptidolipid core antigen for serodiagnosis of Mycobacterium avium complex pulmonary disease in immunocompetent patients","volume":"12","author":"Kitada S","year":"2005","journal-title":"Clin. 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