{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:03:56Z","timestamp":1761987836985,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>The responses of oxygen uptake efficiency (OUE) during cardiopulmonary exercise training (CPET) have not been reported in patients with pulmonary hypertension. We aimed to investigate the differences in OUE<\/jats:styled-content> between patients with idiopathic pulmonary arterial hypertension (IPAH) and chronic thromboembolic pulmonary hypertension (CTEPH<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010four patients with IPAH<\/jats:styled-content> and 29 patients with CTEPH<\/jats:styled-content> were retrospectively enrolled into our study. All patients underwent right\u2010heart catheterization, pulmonary function test and performed the 6\u2010min walk test and CPET<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>We found that oxygen uptake efficiency plateau (OUEP) and oxygen uptake efficiency at anaerobic threshold (OUE@AT) was significantly higher in IPAH<\/jats:styled-content> than that in CTEPH<\/jats:styled-content> (both P<\/jats:italic>\u2009=\u20090.002). However, patients with CTEPH<\/jats:styled-content> had lower mean pulmonary artery pressure, pulmonary vascular resistance and transpulmonary gradient (all P<\/jats:italic>\u2009<\u20090.05). The correlation between OUEP and heart rate at anaerobic threshold (HR_AT) was significant (r = 0.376, P<\/jats:italic> < 0.05); however, no statistically significant correlation was found with ventilation at anaerobic threshold (VE_AT) (r = \u22120.074, P<\/jats:italic> > 0.05) in patients with IPAH. In patients with CTEPH<\/jats:styled-content>, both anaerobic threshold (r\u2009=\u20090.307, P<\/jats:italic>\u2009>\u20090.05) and VE_AT (r\u2009=\u2009\u22120.709, P<\/jats:italic>\u2009<\u20090.0001) were reduced. OUEP<\/jats:styled-content> were higher in WHO<\/jats:styled-content> functional class I<\/jats:styled-content>\/II<\/jats:styled-content> patients than in WHO<\/jats:styled-content> functional class III<\/jats:styled-content>\/IV<\/jats:styled-content> patients (all P<\/jats:italic>\u2009<\u20090.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>OUEP<\/jats:styled-content> and OUE<\/jats:styled-content>@AT<\/jats:styled-content> are higher in IPAH<\/jats:styled-content> than that in CTEPH<\/jats:styled-content> not in proportion to haemodynamics, probably due to differences in cardiac function and pulmonary vascular occlusion. OUEP<\/jats:styled-content> correlates well with the exercise capacity and the severity of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12648","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T10:23:58Z","timestamp":1442917438000},"page":"149-156","source":"Crossref","is-referenced-by-count":14,"title":["Oxygen uptake is more efficient in idiopathic pulmonary arterial hypertension than in chronic thromboembolic pulmonary hypertension"],"prefix":"10.1111","volume":"21","author":[{"given":"Xiaofang","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Pulmonary Circulation Shanghai Pulmonary Hospital Affiliated to Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Function Test Shanghai Pulmonary Hospital Affiliated to Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sugang","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Circulation Shanghai Pulmonary Hospital Affiliated to Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikesh","family":"Sapkota","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Circulation Shanghai Pulmonary Hospital Affiliated to Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Function Test Shanghai Pulmonary Hospital Affiliated to Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Circulation Shanghai Pulmonary Hospital Affiliated to Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Circulation Shanghai Pulmonary Hospital Affiliated to Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Circulation Shanghai Pulmonary Hospital Affiliated to Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingguo","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease Heart\u2010Lung Function Testing Center Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Circulation Shanghai Pulmonary Hospital Affiliated to Tongji University Shanghai China"},{"name":"Department of Pulmonary Function Test Shanghai Pulmonary Hospital Affiliated to Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.029"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi713"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200307-957OC"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000022687.18568.2A"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31817c92c0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00111904"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1270"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.07.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.3.908"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000186694"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1637"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109542"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp297"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1440-2440(03)80268-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-011-2030-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2202033"},{"key":"e_1_2_6_18_1","first-page":"1","article-title":"Anaerobic threshold and cardiovascular function","volume":"58","author":"Wasserman K","year":"2002","journal-title":"Monaldi Arch. 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