{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:41:32Z","timestamp":1761986492140,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001858","name":"Swedish Governmental Agency for Innovation Systems","doi-asserted-by":"crossref","award":["2007-00084"],"award-info":[{"award-number":["2007-00084"]}],"id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Earlier studies on the levels of physical activity in asthma patients compared with controls have yielded varying results. We have previously reported that high versus moderate levels of physical activity were associated with higher prevalence of wheezing, especially in females. Here we studied the levels of physical activity in young patients with asthma and healthy subjects and their effect on asthma control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four hundred eight physician\u2010diagnosed patients with asthma and 118 controls (10\u201334 years) answered questions concerning frequency and\/or duration of physical activity and undertook the Asthma Control Test (<jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content>), spirometry, methacholine challenges and exhaled nitric oxide measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Asthma patients were more frequently physically active (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) and for longer durations (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) than controls. Highly versus moderately physically active patients with asthma had a higher prevalence of not well\u2010controlled asthma (<jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content>\u2009&lt;\u200920) when physical activity was assessed by frequency (40.6% vs 24.1%, <jats:italic>P<\/jats:italic>\u2009=\u20090.001) or duration (39.0% vs 21.7%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). This was only seen in females who had reduced <jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content> items (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Frequently versus moderately active females had an odds ratio of 4.81 (2.43, 9.51) to have <jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content>\u2009&lt;\u200920, while no such effect was found in males (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.18 (0.61, 2.30)) and this interaction was statistically significantly associated with gender (<jats:italic>P<\/jats:italic>\u2009=\u20090.003). No differences in fraction of exhaled nitric oxide or methacholine reactivity were found between moderately and highly physically active females with asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Young asthma patients were more active than controls. High levels of physical activity were associated with poor asthma control as judged by the <jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content> in females, but not in males, and this appears unrelated to airway inflammation or responsiveness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12671","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T05:49:08Z","timestamp":1447912148000},"page":"79-87","source":"Crossref","is-referenced-by-count":9,"title":["High levels of physical activity are associated with poorer asthma control in young females but not in males"],"prefix":"10.1111","volume":"21","author":[{"given":"Ludvig","family":"L\u00f6vstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Clinical Physiology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margareta","family":"Emtner","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Physiotherapy Uppsala University  Uppsala Sweden"},{"name":"Department of Medical Sciences, Respiratory Medicine and Allergology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell","family":"Alving","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Nordvall","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus P.","family":"Borres","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Janson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Respiratory Medicine and Allergology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Malinovschi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Clinical Physiology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.43.10.745"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2011.567426"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.2.432"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-3-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.08.040"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.1997.tb00162.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10900-006-9026-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckr175"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.20.2355"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001116.pub3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.12.980"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12430"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12345"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.068205"},{"key":"e_1_2_7_16_1","unstructured":"WHO | BMI\u2010for\u2010age (5\u201319 years).World Health Organization. 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