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Morphine may disrupt sleep in some conditions and improve sleep quality in others. This study aimed to determine any signal of regular, low\u2010dose morphine on perceived sleep disruption due to breathlessness and perceived sleep quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a secondary analysis of data from 38 participants with refractory breathlessness (30 male; 33 with <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>) aged 76\u2009\u00b1\u20090.9 years who completed a double\u2010blind, randomized, placebo\u2010controlled, cross\u2010over study in which they received 20\u2009mg oral sustained release morphine daily and placebo for 4 days each. Participant ratings of sleep disruption due to breathlessness and perceived sleep quality were obtained daily throughout the 8\u2010day trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Perceived sleep disruption due to breathlessness over the 4\u2010day period ranged between 13% and 32% of participants for placebo and 13% and 26% for morphine, decreasing by each day of the study during the morphine arm. Most participants reported \u2018very good\u2019 or \u2018quite good\u2019 sleep throughout the trial and were less likely to perceive poor sleep quality during the morphine arm (odds ratio\u2009=\u20090.55, 95% confidence interval: 0.34\u20130.88, <jats:italic>P<\/jats:italic>\u2009=\u20090.01). Participants who reported decreased breathlessness during the 4 days on morphine were also likely to report improved sleep quality with morphine (<jats:italic>P<\/jats:italic>\u2009=\u20090.039).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Four days of low\u2010dose morphine improved perceived sleep quality in elderly participants with refractory breathlessness. Regular low\u2010dose morphine targeted to reduce refractory breathlessness may yield associated benefits by reducing sleep disruption and improving sleep quality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12681","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T08:58:37Z","timestamp":1447318717000},"page":"386-391","source":"Crossref","is-referenced-by-count":15,"title":["Effects of low\u2010dose morphine on perceived sleep quality in patients with refractory breathlessness: A hypothesis generating study"],"prefix":"10.1111","volume":"21","author":[{"given":"Rodrigo T.","family":"Martins","sequence":"first","affiliation":[{"name":"Neuroscience Research Australia (NeuRA)  Randwick New South Wales Australia"},{"name":"School of Medical Sciences University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Currow","sequence":"additional","affiliation":[{"name":"Discipline, Palliative and Supportive Services Flinders University  Bedford Park South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy P.","family":"Abernethy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division on Medical Oncology and the Center for Learning Health Care Duke Clinical Research Institute Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Hull York Medical School The University of Hull  Hull UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Toson","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia (NeuRA)  Randwick New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny J.","family":"Eckert","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia (NeuRA)  Randwick New South Wales Australia"},{"name":"School of Medical Sciences University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.523"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.11.021"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7617"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00403581"},{"key":"e_1_2_7_6_1","first-page":"33","article-title":"The effect of opioids on sleep architecture","volume":"3","author":"Dimsdale JE","year":"2007","journal-title":"J. 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