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Lung function changes subsequent to these tests have not been investigated in a general adolescent population, and it remains unknown whether signs of airway inflammation, measured using exhaled nitric oxide (<jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content>), can predict a positive response. The aim of this study was to investigate the temporal aspect of decline in forced expiratory volume in 1\u2009s (FEV<jats:sub>1<\/jats:sub>) after an exercise test using dry air, and to investigate predictors of <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From a cross\u2010sectional study on adolescents aged 13\u201315 years (<jats:italic>n<\/jats:italic>\u2009=\u20093838), a random subsample of 146 adolescents (99 with and 47 without self\u2010reported exercise\u2010induced dyspnoea) underwent standardized treadmill exercise tests for <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content> while breathing dry air.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the adolescents, 34% had a positive <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content> test (decline of \u226510% in FEV<jats:sub>1<\/jats:sub> from baseline) within 30\u2009min. Of the subjects with <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content>, 53% showed the greatest decline in FEV<jats:sub>1<\/jats:sub> at 5 to 10\u2009min (mean decline 18.5%), and the remaining 47% of the subjects showed the greatest decline at 15 to 30\u2009min (mean decline 18.9%) after exercise. Increased <jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content> (&gt;20\u2009ppb), female gender and self\u2010reported exercise\u2010induced dyspnoea were independently associated with a positive <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When assessing general adolescents for <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content> with exercise test using dry air, there is a temporal variation in the greatest FEV<jats:sub>1<\/jats:sub> decline after exercise. Therefore, lung function should be measured for at least 30\u2009min after the exercise. Increased <jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content>, female gender and self\u2010reported exercise\u2010induced dyspnoea can be predictors of a positive <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content> test.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12682","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T16:00:24Z","timestamp":1448035224000},"page":"289-296","source":"Crossref","is-referenced-by-count":17,"title":["Exercise test using dry air in random adolescents: Temporal profile and predictors of bronchoconstriction"],"prefix":"10.1111","volume":"21","author":[{"given":"Henrik","family":"Johansson","sequence":"first","affiliation":[{"name":"Neuroscience\/Physiotherapy and Medical Sciences Respiratory Medicine and Allergology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Norlander","sequence":"additional","affiliation":[{"name":"Surgical Sciences: Otolaryngology and Head and Neck Surgery Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell","family":"Alving","sequence":"additional","affiliation":[{"name":"Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Hedenstr\u00f6m","sequence":"additional","affiliation":[{"name":"Medical Sciences Clinical Physiology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Janson","sequence":"additional","affiliation":[{"name":"Medical Sciences Respiratory Medicine and Allergology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Malinovschi","sequence":"additional","affiliation":[{"name":"Medical Sciences Clinical Physiology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif","family":"Nordang","sequence":"additional","affiliation":[{"name":"Surgical Sciences: Otolaryngology and Head and Neck Surgery Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margareta","family":"Emtner","sequence":"additional","affiliation":[{"name":"Neuroscience\/Physiotherapy and Medical Sciences Respiratory Medicine and Allergology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.070169"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2014.03.010"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00095803"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.09.021"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0437ST"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205738"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20185"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09102094"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2011.578315"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.5.1112"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.125729"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e3180986e45"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10112662"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.ats11-99"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(77)90119-1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1183\/09031936.93.04080979","article-title":"Influence of water content of inspired air during and after exercise on induced bronchoconstriction","volume":"4","author":"Boulet LP","year":"1991","journal-title":"Eur. 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