{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:02:25Z","timestamp":1777536145673,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T00:00:00Z","timestamp":1449619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>Obesity is associated with increased dyspnoea and reduced health status in patients with chronic obstructive pulmonary disease (COPD<\/jats:styled-content>). Studies on the effects of obesity on exercise capacity showed divergent results. The objective of this study is to investigate the impact of obesity on weight\u2010bearing versus weight\u2010supported exercise tolerance in obese and normal weight patients, matched for age, gender and degree of airflow limitation.<\/jats:p><\/jats:sec>Methods<\/jats:title>Retrospective analyses of data obtained during pre\u2010pulmonary rehabilitation assessment in 108 obese COPD<\/jats:styled-content> patients (OB<\/jats:styled-content>) (age: 61.2\u2009\u00b1\u20095.3y, FEV<\/jats:styled-content>1<\/jats:sub>: 43.2\u2009\u00b1\u20097.4%, BMI<\/jats:styled-content>: 34.1\u2009\u00b1\u20093.9\u2009kg\/m2<\/jats:sup>,) and 108 age and FEV<\/jats:styled-content>1<\/jats:sub>\u2010matched normal weight COPD<\/jats:styled-content> patients (NW<\/jats:styled-content>) (age: 61.7\u2009\u00b1\u20093.6y, FEV<\/jats:styled-content>1<\/jats:sub>: 41.5\u2009\u00b1\u20098.4%, BMI<\/jats:styled-content>: 22.9\u2009\u00b1\u20091.2\u2009kg\/m2<\/jats:sup>,). Cardiopulmonary exercise test (CPET<\/jats:styled-content>) and 6\u2009min walk test (6MWT<\/jats:styled-content>) were performed, B<\/jats:styled-content>org scores for dyspnoea and leg fatigue were recorded, before and after the tests.<\/jats:p><\/jats:sec>Results<\/jats:title>Six\u2010minute walk distance differed between OB<\/jats:styled-content> (398\u2009\u00b1\u2009107\u2009m) and NW<\/jats:styled-content> patients (446\u2009\u00b1\u2009109\u2009m, P<\/jats:italic>\u2009<\u20090.05), while peak cycling exercise load was comparable (OB<\/jats:styled-content>: 75\u2009\u00b1\u200929\u2009W, NW<\/jats:styled-content>: 70\u2009\u00b1\u200925\u2009W, ns). Dyspnoea (OB<\/jats:styled-content> 3.2\u2009\u00b1\u20092.0 vs NW<\/jats:styled-content> 3.1\u2009\u00b1\u20091.7, ns) and leg fatigue (OB<\/jats:styled-content> 2.4\u2009\u00b1\u20092.3 vs NW<\/jats:styled-content> 1.9\u2009\u00b1\u20091.7, ns) were not significantly different in OB<\/jats:styled-content> compared with NW<\/jats:styled-content> after 6MWT, or after CPET<\/jats:styled-content> (dyspnoea: OB<\/jats:styled-content> 5.1\u2009\u00b1\u20092.4 vs NW<\/jats:styled-content> 5.4\u2009\u00b1\u20092.2, ns; leg fatigue: OB<\/jats:styled-content> 4.0\u2009\u00b1\u20092.3 vs NW<\/jats:styled-content> 4.0\u2009\u00b1\u20092.7, ns).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In contrast to weight\u2010supported exercise, obesity has a negative impact on weight\u2010bearing exercise capacity, despite comparable exercise\u2010related symptoms. The results of this study enhance the understanding of the impact of obesity on physical performance in COPD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12700","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T17:44:11Z","timestamp":1449769451000},"page":"483-488","source":"Crossref","is-referenced-by-count":19,"title":["Effects of obesity on weight\u2010bearing versus weight\u2010supported exercise testing in patients with COPD"],"prefix":"10.1111","volume":"21","author":[{"given":"Robbert C.","family":"Maatman","sequence":"first","affiliation":[{"name":"Department of Research and Education CIRO+, Centre of Expertise for Chronic Organ Failure Horn The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn A.","family":"Spruit","sequence":"additional","affiliation":[{"name":"Department of Research and Education CIRO+, Centre of Expertise for Chronic Organ Failure Horn The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula P.","family":"van Melick","sequence":"additional","affiliation":[{"name":"Department of Research and Education CIRO+, Centre of Expertise for Chronic Organ Failure Horn The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos P.I.","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Research and Education CIRO+, Centre of Expertise for Chronic Organ Failure Horn The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica P.A.","family":"Rutten","sequence":"additional","affiliation":[{"name":"Department of Research and Education CIRO+, Centre of Expertise for Chronic Organ Failure Horn The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lowie E.G.W.","family":"Vanfleteren","sequence":"additional","affiliation":[{"name":"Department of Research and Education CIRO+, Centre of Expertise for Chronic Organ Failure Horn The Netherlands"},{"name":"Department of Respiratory Medicine Maastricht University Medical Centre (MUMC+) Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiel F.M.","family":"Wouters","sequence":"additional","affiliation":[{"name":"Department of Research and Education CIRO+, Centre of Expertise for Chronic Organ Failure Horn The Netherlands"},{"name":"Department of Respiratory Medicine Maastricht University Medical Centre (MUMC+) Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frits M.E.","family":"Franssen","sequence":"additional","affiliation":[{"name":"Department of Research and Education CIRO+, Centre of Expertise for Chronic Organ Failure Horn The Netherlands"},{"name":"Department of Respiratory Medicine Maastricht University Medical Centre (MUMC+) Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,9]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WHO.Obesity: preventing and managing the global epidemic.Report of a WHO consultation. 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