{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:03:36Z","timestamp":1761419016323},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,6]],"date-time":"2015-12-06T00:00:00Z","timestamp":1449360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>s compliance of continuous positive airway pressure (<jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>) for treatment of obstructive sleep apnoea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>) is often suboptimal, a less cumbersome treatment is desirable. We explored the clinical usefulness of nasal positive end expiratory pressure (n<jats:styled-content style=\"fixed-case\">PEEP<\/jats:styled-content>) valves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Symptomatic <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> patients (apnoea hypopnea index (<jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>)\u2009&gt;5\/h by polysomnography (<jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content>) or &gt;10\/h by type <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> devices), who declined <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>, were recruited. A nPEEP valve was attached to each nostril before bed. After successful acclimatization for 1 week, treatment was continued for 4 weeks. The n<jats:styled-content style=\"fixed-case\">PEEP<\/jats:styled-content> valves provided expiratory resistance to build up <jats:styled-content style=\"fixed-case\">PEEP<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content> was performed at week 4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 196 subjects, 46 (23%) failed acclimatization and 14 (7%) withdrew. Among the 120 patients with a valid <jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content>, 72 (60%) and 75 (63%) had &gt;50% reduction in mean (standard deviation) overall <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> 26 (16)\/h to 18 (18)\/h and mean supine <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> 31 (19)\/h to 11(16)\/h, respectively, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001. Compared with responders, patients with &lt;50% reduction in <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> had a higher mean overall <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> (30\/h vs 23\/h, <jats:italic>P<\/jats:italic>\u2009=\u20090.03), higher mean supine <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> (35\/h vs 26\/h, <jats:italic>P<\/jats:italic>\u2009=\u20090.04), more severe mean oxygen desaturation nadir (76.7% vs 82.7%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and longer mean period of desaturation\u2009&lt;90% SaO<jats:sub>2<\/jats:sub> (7.7 vs 2.4, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). Breathing discomfort and dry mouth were the most common side effects. Compared with a dental device, there was a larger mean reduction in supine <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> using n<jats:styled-content style=\"fixed-case\">PEEP<\/jats:styled-content> (29 (14)\/h vs 16 (17)\/h).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>nPEEP valves were useful in selected patients with mild or positional\u2010related <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12703","type":"journal-article","created":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T01:43:36Z","timestamp":1449452616000},"page":"541-545","source":"Crossref","is-referenced-by-count":4,"title":["Role of nasal positive end expiratory pressure valve as an alternative treatment for obstructive sleep apnoea in <scp>C<\/scp>hinese patients"],"prefix":"10.1111","volume":"21","author":[{"given":"Kin Wang","family":"To","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine Department of Medicine and Therapeutics Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tat O.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Department of Medicine and Therapeutics Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Department of Medicine and Therapeutics Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Ngai","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Department of Medicine and Therapeutics Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David SC.","family":"Hui","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Department of Medicine and Therapeutics Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.1.127"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.14.1906"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27191"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2008.04.025"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldh044"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.3.381"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.007195"},{"key":"e_1_2_7_11_1","first-page":"36","article-title":"The influence of CPAP on the neurobehavioral performance of patients with obstructive sleep apnea hypopnea syndrome: a systematic review","volume":"102","author":"McMahon JP","year":"2003","journal-title":"WMJ"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcp.0000245715.97256.32"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200111000-00005"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109023"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/00151829-200504060-00005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2038"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.2.244"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256646"},{"key":"e_1_2_7_19_1","first-page":"1389","article-title":"Sleep disorders: diagnosis and treatment","volume":"55","author":"Dhand R","year":"2010","journal-title":"Respir. 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