{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:43:25Z","timestamp":1791272605242,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T00:00:00Z","timestamp":1449532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Actelion Laboratory"},{"name":"Inserm\/InCA\/DHOS Recherche Clinique Translationnelle 2007"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"Abstract<\/jats:title>Background and objective<\/jats:title>Randomized controlled trials (RCT<\/jats:styled-content>) have shown that continuous positive airway pressure (CPAP<\/jats:styled-content>) has only limited impact on blood pressure (BP<\/jats:styled-content>). Alternative strategies for obstructive sleep apnoea (OSA<\/jats:styled-content>)\u2010associated hypertension are therefore needed. Endothelin\u20101 has been demonstrated a key player in the deleterious cardiovascular consequences of OSA<\/jats:styled-content>. In OSA<\/jats:styled-content>, CPAP<\/jats:styled-content> treatment has never been compared with endothelin receptor antagonist medications. Thus, we assessed the respective efficacy of CPAP<\/jats:styled-content> and bosentan in reducing 24\u2010h diastolic BP<\/jats:styled-content> (DBP<\/jats:styled-content>) in patients with OSA<\/jats:styled-content> never treated by either therapy.<\/jats:p><\/jats:sec>Methods<\/jats:title>In a crossover pilot study, 16 mildly hypertensive patients (office systolic BP<\/jats:styled-content> (SBP<\/jats:styled-content>)\/DBP<\/jats:styled-content>: 142\u2009\u00b1\u20097\/85\u2009\u00b1\u20098\u2009mm\u2009Hg) with severe OSA<\/jats:styled-content> (55\u2009\u00b1\u20098 years; body mass index, 29.6\u2009\u00b1\u20094.2\u2009kg\/m2<\/jats:sup>; apnoea\u2013hypopnoea index, 40.8\u2009\u00b1\u200920.2\/h) were randomized to either CPAP<\/jats:styled-content> (n<\/jats:italic>\u2009=\u20097) or bosentan (125\u2009mg\/day, n<\/jats:italic>\u2009=\u20099) first for 4 weeks. After 2\u2010weeks of washout, the second 4\u2010week period consisted of the alternative treatment (in crossover). The primary outcome was the 24\u2010h mean DBP<\/jats:styled-content> change after treatment.<\/jats:p><\/jats:sec>Results<\/jats:title>In intention\u2010to\u2010treat analysis, the mean difference in 24\u2010h DBP<\/jats:styled-content> measurements between treatments was \u22123.1 (\u22126.9\/0.7)\u2009mm\u2009Hg (median, 25th\/75th percentiles) (P<\/jats:italic>\u2009=\u20090.101) with bosentan having a greater effect.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In this RCT<\/jats:styled-content>, in mildly hypertensive patients with OSA<\/jats:styled-content>, bosentan did not modify 24\u2010h DBP<\/jats:styled-content> but only reduced office BP<\/jats:styled-content> suggesting that Endothelin\u20101 blockade does not play a major role in treatment of OSA<\/jats:styled-content>\u2010related hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12713","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T10:35:49Z","timestamp":1449657349000},"page":"546-552","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of continuous positive airway pressure and bosentan effect in mildly hypertensive patients with obstructive sleep apnoea: A randomized controlled pilot study"],"prefix":"10.1111","volume":"21","author":[{"given":"Marie","family":"Joyeux\u2010Faure","sequence":"first","affiliation":[{"name":"HP2 Laboratory Inserm U1042 Grenoble Alpes University Grenoble France"},{"name":"Department of Physiology and Sleep Grenoble University Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Jullian\u2010Desayes","sequence":"additional","affiliation":[{"name":"HP2 Laboratory Inserm U1042 Grenoble Alpes University Grenoble France"},{"name":"Department of Physiology and Sleep Grenoble University Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Pepin","sequence":"additional","affiliation":[{"name":"HP2 Laboratory Inserm U1042 Grenoble Alpes University Grenoble France"},{"name":"Department of Physiology and Sleep Grenoble University Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Luc","family":"Cracowski","sequence":"additional","affiliation":[{"name":"HP2 Laboratory Inserm U1042 Grenoble Alpes University Grenoble France"},{"name":"Clinical Investigation Centre Grenoble University Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Baguet","sequence":"additional","affiliation":[{"name":"Cardiology Department Grenoble University Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Tamisier","sequence":"additional","affiliation":[{"name":"HP2 Laboratory Inserm U1042 Grenoble Alpes University Grenoble France"},{"name":"Department of Physiology and Sleep Grenoble University Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Levy","sequence":"additional","affiliation":[{"name":"HP2 Laboratory Inserm U1042 Grenoble Alpes University Grenoble France"},{"name":"Department of Physiology and Sleep Grenoble University Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Godin\u2010Ribuot","sequence":"additional","affiliation":[{"name":"HP2 Laboratory Inserm U1042 Grenoble Alpes University Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine H","family":"Launois","sequence":"additional","affiliation":[{"name":"HP2 Laboratory Inserm U1042 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