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Static pulmonary hyperinflation is a key determinant of exercise performance, but its effect on the longitudinal decline in exercise capacity remains unknown. We aimed to study the relationship between the inspiratory capacity\u2010to\u2010total lung capacity (<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content>) ratio and exercise capacity decline in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content> and other relevant clinical and functional variables in 342 clinically stable patients with <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>. The 6\u2010min walk distance (<jats:styled-content style=\"fixed-case\">6MWD<\/jats:styled-content>) was determined at recruitment and after a mean\u2009\u00b1\u2009<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> of 1.7\u2009\u00b1\u20090.3 years. The annual rate of change in <jats:styled-content style=\"fixed-case\">6MWD<\/jats:styled-content> was calculated. Multiple imputation to account for losses during follow up was implemented, and multivariate regression was used to analyze predictive factors of <jats:styled-content style=\"fixed-case\">6MWD<\/jats:styled-content> decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean decline rate in the <jats:styled-content style=\"fixed-case\">6MWD<\/jats:styled-content> was 21.9\u2009\u00b1\u200934.1\u2009m\/year. In the bivariate analysis, patients with lower levels of <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content> had greater <jats:styled-content style=\"fixed-case\">6MWD<\/jats:styled-content> decline (\u221227.4\u2009\u00b1\u200942.5, \u221224.9\u2009\u00b1\u200936.5 and \u221213.4\u2009\u00b1\u200939.9\u2009m\/year in the first, second and third tertile of <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content>, respectively; <jats:italic>P<\/jats:italic>\u2010for\u2010trend\u2009=\u20090.018). From other potential risk factors considered, dyspnoea, health status, serum <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>org dyspnoea score at the end of the exercise test were related to exercise capacity decline. In the multivariate regression model, only <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content> (\u03b2\u2009=\u20090.7\u2009m\/year per each percentage unit of <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content>; <jats:italic>P<\/jats:italic>\u2009=\u20090.007) and dyspnoea (<jats:styled-content style=\"fixed-case\">mMRC<\/jats:styled-content>\u2009\u2265\u20092) (\u03b2\u2009=\u2009\u221214.6\u2009m\/year; <jats:italic>P<\/jats:italic>\u2009=\u20090.013) were associated with the annual rate of <jats:styled-content style=\"fixed-case\">6MWD<\/jats:styled-content> change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content> and dyspnoea in clinically stable patients with <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> predict their exercise capacity decline and may help to guide early therapeutic interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12723","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T08:24:50Z","timestamp":1451463890000},"page":"476-482","source":"Crossref","is-referenced-by-count":17,"title":["Inspiratory capacity\u2010to\u2010total lung capacity ratio and dyspnoea predict exercise capacity decline in <scp>COPD<\/scp>"],"prefix":"10.1111","volume":"21","author":[{"given":"Maria A.","family":"Ramon","sequence":"first","affiliation":[{"name":"Department of Pneumology Hospital Universitari Vall d'Hebron  Barcelona Spain"},{"name":"Departament de Medicina Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Barcelona 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