{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:36:58Z","timestamp":1778607418667,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T00:00:00Z","timestamp":1458345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Japan Agency for Medical Research and Development, AMED","award":["15ek0109064h0002"],"award-info":[{"award-number":["15ek0109064h0002"]}]},{"name":"Ministry of Health, Labour and Welfare of Japan"},{"name":"Diffuse Pulmonary Disorders, Scientific Research\/Research","award":["H26-Nanchi-Ippan-065"],"award-info":[{"award-number":["H26-Nanchi-Ippan-065"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Myeloperoxidase anti\u2010neutrophil cytoplasmic antibody (MPO\u2010ANCA) is occasionally positive in patients with usual interstitial pneumonia (UIP). However, the differences from idiopathic pulmonary fibrosis (IPF\/UIP) have not been well documented. We aimed to clarify the clinical, radiological and pathological features of UIP associated with MPO\u2010ANCA (ANCA\/UIP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the medical records of 12 consecutive ANCA\/UIP patients not manifesting microscopic polyangiitis and 108 IPF\/UIP patients with no autoantibodies, both diagnosed by surgical lung biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in clinical background, laboratory results and pulmonary function tests between ANCA\/UIP patients and IPF\/UIP patients except for the percentage of bronchoalveolar lavage neutrophils. HRCT showed subpleural reticulation in both groups. Increased attenuation around honeycombing and cysts was significantly observed in ANCA\/UIP. Pathologically, ANCA\/UIP had more prominent inflammatory cell infiltration, lymphoid follicles with germinal centres and cellular bronchiolitis. During the disease course, three of 12 patients (25%) developed microscopic polyangiitis. Immunosuppressive treatment tended to be more effective in ANCA\/UIP patients, and the survival time in ANCA\/UIP patients tended to be longer than those with IPF\/UIP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ANCA\/UIP may be distinguishable from IPF\/UIP with a combination of HRCT findings of increased attenuation around honeycombing and cysts and some of the characteristic pathological findings. In contrast to IPF\/UIP, immunosuppressive treatment could be a therapeutic option for ANCA\/UIP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12763","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T15:50:30Z","timestamp":1458402630000},"page":"920-926","source":"Crossref","is-referenced-by-count":70,"title":["Clinical features of usual interstitial pneumonia with anti\u2010neutrophil cytoplasmic antibody in comparison with idiopathic pulmonary fibrosis"],"prefix":"10.1111","volume":"21","author":[{"given":"Chiaki","family":"Hosoda","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Kanagawa Cardiovascular and Respiratory Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohisa","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kanagawa Cardiovascular and Respiratory Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kanagawa Cardiovascular and Respiratory Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kanagawa Cardiovascular and Respiratory Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norikazu","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kanagawa Cardiovascular and Respiratory Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideya","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kanagawa Cardiovascular and Respiratory Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae","family":"Iwasawa","sequence":"additional","affiliation":[{"name":"Department of Radiology Kanagawa Cardiovascular and Respiratory Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Okudela","sequence":"additional","affiliation":[{"name":"Department of Pathology, Graduate School of Medicine Yokohama City University  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamiko","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Pathology Japan Red Cross Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kanagawa Cardiovascular and Respiratory Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:3<421::AID-ANR5>3.0.CO;2-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62575-0"},{"key":"e_1_2_7_4_1","first-page":"384","article-title":"Four cases of anti\u2010myeloperoxidase antibody\u2010related rapidly progressive glomerulonephritis during the course of idiopathic pulmonary fibrosis","volume":"53","author":"Hiromura K","year":"2000","journal-title":"Clin. 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