{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:28:55Z","timestamp":1783074535768,"version":"3.54.6"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T00:00:00Z","timestamp":1458691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Public Health Ontario Project Initiation Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nontuberculous mycobacterial (NTM) infections are increasing in disease frequency worldwide. This systematic review examines health\u2010related quality of life (HRQOL), comorbidities and mortality associated with pulmonary NTM disease. We searched MEDLINE, EMBASE, CINAHL, Scopus Life Sciences, conference proceedings and Google (earliest date available to February 2015) for primary studies. Eligible studies compared populations with and without pulmonary NTM disease in high\u2010income jurisdictions. We excluded studies on HIV\/AIDS. All languages were accepted. Two reviewers followed MOOSE and PRISMA reporting guidelines and independently appraised quality using STROBE. All studies were summarized qualitatively regardless of quality. Of 3193 citations screened, we included 17 studies mostly from Taiwan (<jats:italic>n<\/jats:italic>\u2009=\u20095) and the USA (<jats:italic>n<\/jats:italic>\u2009=\u20094). Two studies assessed HRQOL; one assessed comorbidities, 11 assessed mortality, and three assessed multiple outcomes. Populations with pulmonary NTM reported significantly worse or similar HRQOL than the general population, depending on the instruments used. Some suggested greater prevalence of having bronchiectasis (<jats:italic>n<\/jats:italic>\u2009=\u20092) and greater risk of developing pulmonary tuberculosis (<jats:italic>n<\/jats:italic>\u2009=\u20091). Most (<jats:italic>n<\/jats:italic>\u2009=\u20097) suggested no difference in mortality, although only one was age\u2010matched and gender\u2010matched to the general population. Four suggested NTM populations had higher mortality\u2014two of which compared with the general population and were deemed of high quality, while two compared with non\u2010NTM patients from hospital. High clinical heterogeneity in study design may explain discordant results. Bias assessments and controlling for confounding were carried out poorly. No consistent trends were observed although there is suggestion of an increased health burden from respiratory diseases and increased mortality associated with pulmonary NTM disease.<\/jats:p>","DOI":"10.1111\/resp.12767","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T00:06:55Z","timestamp":1458778015000},"page":"1015-1025","source":"Crossref","is-referenced-by-count":30,"title":["Health\u2010related quality of life, comorbidities and mortality in pulmonary nontuberculous mycobacterial infections: A systematic review"],"prefix":"10.1111","volume":"21","author":[{"given":"Man Wah","family":"Yeung","sequence":"first","affiliation":[{"name":"Public Health Ontario  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Khoo","sequence":"additional","affiliation":[{"name":"Public Health Ontario  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Brode","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Toronto  Toronto Ontario Canada"},{"name":"West Park Healthcare Centre  Toronto Ontario Canada"},{"name":"University Health Network and Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances B.","family":"Jamieson","sequence":"additional","affiliation":[{"name":"Public Health Ontario  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Japanese Red Cross Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Kwong","sequence":"additional","affiliation":[{"name":"Public Health Ontario  Toronto Ontario Canada"},{"name":"University Health Network and Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"Institute for Clinical Evaluative Sciences  Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Department of Family and Community Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liane","family":"Macdonald","sequence":"additional","affiliation":[{"name":"Public Health Ontario  Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore K.","family":"Marras","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Toronto  Toronto Ontario Canada"},{"name":"University Health Network and Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center, Fukujuji Hospital Japan Anti\u2010Tuberculosis Association  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Sander","sequence":"additional","affiliation":[{"name":"Public Health Ontario  Toronto Ontario Canada"},{"name":"Institute for Clinical Evaluative Sciences  Toronto Ontario Canada"},{"name":"Institute of Health Policy Management and Evaluation at the University of Toronto  Toronto Ontario Canada"},{"name":"Toronto Health Economics and Technology Assessment (THETA) collaborative  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60632-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1333569"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-004-4001-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.070797"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200702-201OC"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1610.091201"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.2.330"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12440"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091879"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.75.2.120"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8479(94)90080-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198909283211304"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2010.535558"},{"key":"e_1_2_7_16_1","first-page":"1","article-title":"Antibiotic treatment for nontuberculous mycobacteria lung infection in people with cystic fibrosis","volume":"12","author":"Waters V","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","unstructured":"International Monetary Fund.World Economic Outlook\u2014Recovery Strengthens Remains Uneven. Washington DC; April 2014. [Accessed February 2015]. Available from: URLhttp:\/\/www.imf.org\/external\/pubs\/ft\/weo\/2014\/01\/pdf\/text.pdf","DOI":"10.5089\/9781475571615.081"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.1.4"},{"key":"e_1_2_7_21_1","first-page":"831","article-title":"Tuberculosis sequelae: clinical aspects","volume":"65","author":"Harada S","year":"1990","journal-title":"Kekkaku"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-014-0727-3"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.08.004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00139005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200905-0778OC"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2058"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1407-7"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.04.017"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2012.722227"},{"key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/ctr.12140","article-title":"Lung transplant outcomes in cystic fibrosis patients with pre\u2010operative Mycobacterium abscessus respiratory infections","volume":"27","author":"Lobo LJ","journal-title":"Clin. Transplant."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel206"},{"key":"e_1_2_7_32_1","first-page":"635","article-title":"Non\u2010tuberculous mycobacterial pleurisy: an 8\u2010year single\u2010centre experience in Taiwan","volume":"14","author":"Shu C\u2010C","year":"2010","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1221-6"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704043"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-2016OC"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.12.0675"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(00)00237-4"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03547.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.096842"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.866"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.12.160"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-010-9241-8"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201003-0503OC"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2007.01.008"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.3.167"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00149212"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0954-6111(95)90063-2"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200207-678OC"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.4.16141"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2049"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.12767","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.12767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:21:42Z","timestamp":1696177302000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.12767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,23]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/resp.12767"],"URL":"https:\/\/doi.org\/10.1111\/resp.12767","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,23]]}}}