{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:32:59Z","timestamp":1790742779225,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI Grand","award":["26462767"],"award-info":[{"award-number":["26462767"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>Sepsis is a leading cause of acute lung injury (ALI); however, the characteristics and outcome of sepsis\u2010associated ALI are poorly understood. We aimed to elucidate factors that predict patient outcome in sepsis\u2010associated ALI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Secondary analysis of a multicenter, prospective, observational study was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 624 patients with severe sepsis and septic shock, 251 (40.2%) fulfilled the definition of American\u2013European Consensus Conference definition of ALI. All\u2010cause 28\u2010day and in\u2010hospital mortalities were 30.7% and 38.6%, respectively. More than 40% of ALI patients had neurological, cardiovascular and haematological dysfunctions or disseminated intravascular coagulation, all of which were associated with higher mortality. We report a significant correlation between infection site and mortality in patients with ALI, but not in those without ALI. The proportion of ALI was significantly higher in pulmonary sepsis; further, a complication of ALI was associated with higher mortality in sepsis from pulmonary and other sources, but not in abdominal sepsis. Among the other sepsis sites, urinary tract, central nervous system, catheter\u2010related and undetermined foci of infection had worse outcomes when associated with ALI. None of the individual severe sepsis bundles, including fluid resuscitation and early antibiotic administration, correlated with mortality. Compliance with a set of sepsis management bundles was associated with better outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In severe sepsis and septic shock, the proportion and effect on outcome was not uniform among infection sites. The infection site was predictive of outcome in patients with ALI but not in those without ALI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/resp.12769","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T16:56:43Z","timestamp":1459443403000},"page":"898-904","source":"Crossref","is-referenced-by-count":51,"title":["Infection site is predictive of outcome in acute lung injury associated with severe sepsis and septic shock"],"prefix":"10.1111","volume":"21","author":[{"given":"Seitaro","family":"Fujishima","sequence":"first","affiliation":[{"name":"Center for General Medicine Education, School of Medicine Keio University  Minato Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Gando","sequence":"additional","affiliation":[{"name":"Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saitoh","family":"Daizoh","sequence":"additional","affiliation":[{"name":"Division of Traumatology, Research Institute National Defense Medical College  Tokorozawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Kushimoto","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Mayumi","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Occupational and Environmental Health  Kitakyushu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotsugu","family":"Takuma","sequence":"additional","affiliation":[{"name":"Emergency &amp; Critical Care Center Kawasaki Municipal Hospital  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joji","family":"Kotani","sequence":"additional","affiliation":[{"name":"Department of Emergency, Critical Care and Disaster Medicine Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Emergency &amp; Critical Care Medicine, School of Medicine Kurume University  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Advanced Medical Emergency &amp; Critical Care Center Yamaguchi University Hospital  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoshi","family":"Takeyama","sequence":"additional","affiliation":[{"name":"Department of Emergency and Acute Intensive Care Medicine Fujita Health University  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010ichiro","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunetoshi","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Emergency &amp; Critical Care Medicine Trauma Center St. Mary's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Acute Medicine Kawasaki Medical School  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Trauma and Resuscitation Center Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Miki","sequence":"additional","affiliation":[{"name":"Advanced Critical Care Center Aichi Medical University Hospital  Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Iwate Medical University  Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Trauma &amp; 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