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This review focuses on several aspects of acute exacerbation of COPD (AECOPD) including epidemiology, diagnosis and management. COPD poses a major health and economic burden in the Asia\u2010Pacific region, as it does worldwide. Triggering factors of AECOPD include infectious (bacteria and viruses) and environmental (air pollution and meteorological effect) factors. Disruption in the dynamic balance between the \u2018pathogens\u2019 (viral and bacterial) and the normal bacterial communities that constitute the lung microbiome likely contributes to the risk of exacerbations. The diagnostic approach to AECOPD varies based on the clinical setting and severity of the exacerbation. After history and examination, a number of investigations may be useful, including oximetry, sputum culture, chest X\u2010ray and blood tests for inflammatory markers. Arterial blood gases should be considered in severe exacerbations, to characterize respiratory failure. Depending on the severity, the acute management of AECOPD involves use of bronchodilators, steroids, antibiotics, oxygen and noninvasive ventilation. Hospitalization may be required, for severe exacerbations. Nonpharmacological interventions including disease\u2010specific self\u2010management, pulmonary rehabilitation, early medical follow\u2010up, home visits by respiratory health workers, integrated programmes and telehealth\u2010assisted hospital at home have been studied during hospitalization and shortly after discharge in patients who have had a recent AECOPD. Pharmacological approaches to reducing risk of future exacerbations include long\u2010acting bronchodilators, inhaled steroids, mucolytics, vaccinations and long\u2010term macrolides. Further studies are needed to assess the cost\u2010effectiveness of these interventions in preventing COPD exacerbations.<\/jats:p>","DOI":"10.1111\/resp.12780","type":"journal-article","created":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T01:54:43Z","timestamp":1459475683000},"page":"1152-1165","source":"Crossref","is-referenced-by-count":319,"title":["Acute exacerbation of COPD"],"prefix":"10.1111","volume":"21","author":[{"given":"Fanny W.","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-5846","authenticated-orcid":false,"given":"Ka Pang","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Goddard","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland Brisbane Australia"},{"name":"Department of Thoracic Medicine The Prince Charles Hospital, Metro North Hospital and Health District Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet G.","family":"Shaw","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland Brisbane Australia"},{"name":"Department of Thoracic Medicine The Prince Charles Hospital, Metro North Hospital and Health District Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Reid","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland Brisbane Australia"},{"name":"Department of Thoracic Medicine The Prince Charles Hospital, Metro North Hospital and Health District Brisbane Australia"},{"name":"Lung Infection and Inflammation Laboratory QIMR Berghofer Medical Research Institute Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland Brisbane Australia"},{"name":"Department of Thoracic Medicine The Prince Charles Hospital, Metro North Hospital and Health District Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61377-4"},{"key":"e_1_2_10_3_1","first-page":"713","article-title":"Worldwide burden of COPD in high\u2010 and low\u2010income countries. 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