{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:06:00Z","timestamp":1715569560385},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2011BAI11B15"],"award-info":[{"award-number":["2011BAI11B15"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"ABSTRACT<\/jats:title>Background and objective<\/jats:title>The potential prognostic value of cardiovascular magnetic resonance (CMR<\/jats:styled-content>)\u2010derived right ventricular (RV<\/jats:styled-content>) ejection\/filling parameters in the assessment of RV<\/jats:styled-content> function remains to be fully established. The goal of this study was to explore the prognostic value of these parameters in idiopathic pulmonary arterial hypertension (IPAH<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this prospective investigation, newly diagnosed IPAH<\/jats:styled-content> patients without targeted therapy were recruited. Patients underwent right heart catheterization (RHC<\/jats:styled-content>), 6\u2010min walk test and CMR<\/jats:styled-content> imaging within 1\u2009week. Cardiopulmonary haemodynamics derived from RHC<\/jats:styled-content>, and RV<\/jats:styled-content> ejection\/filling parameters derived from CMR<\/jats:styled-content> were collected.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 41 IPAH<\/jats:styled-content> patients were recruited with the median follow\u2010up time of 824\u2009days. During this period, 13 patients significantly deteriorated and among them, 7 patients died. CMR<\/jats:styled-content>\u2010derived RV<\/jats:styled-content> peak ejection rate (PER<\/jats:styled-content>) correlated significantly with CMR<\/jats:styled-content>\u2010derived RV<\/jats:styled-content> stroke volume index (r\u2009=\u20090.574, P<\/jats:italic>\u2009<\u20090.001) and RV<\/jats:styled-content> cardiac index (r\u2009=\u20090.611, P<\/jats:italic>\u2009<\u20090.001), but had no significant correlation with RV<\/jats:styled-content> end diastolic volume index (EDVI<\/jats:styled-content>, r\u2009=\u20090.201, P<\/jats:italic>\u2009=\u20090.208) and pulmonary vascular resistance (r\u2009=\u2009\u22120.134, P<\/jats:italic>\u2009=\u20090.403). Multivariate Cox regression analysis showed that RV<\/jats:styled-content> time to PER<\/jats:styled-content> (TPER<\/jats:styled-content>, hazard ratio (HR<\/jats:styled-content>)\u2009=\u20091.010, 95% CI<\/jats:styled-content>: 1.003\u20131.017, P<\/jats:italic>\u2009=\u20090.005) and RV TPER<\/jats:styled-content>\/time of a cardiac cycle (TPER<\/jats:styled-content>\/TCC<\/jats:styled-content>, HR<\/jats:styled-content>\u2009=\u20091.085, 95% CI<\/jats:styled-content>: 1.031\u20131.141, P<\/jats:italic>\u2009=\u20090.002) were predictors of clinical deterioration after adjusting for N\u2010terminal pro\u2010brain natriuretic peptide (NT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content>) and RV EDVI<\/jats:styled-content>. Kaplan\u2013Meier survival analyses showed that patients with RV TPER<\/jats:styled-content>\u2009\u2265\u2009199.01\u2009ms (log rank: P<\/jats:italic>\u2009=\u20090.036) or RV TPER<\/jats:styled-content>\/TCC<\/jats:styled-content>\u2009\u2265\u200920.02% (log rank: P<\/jats:italic>\u2009=\u20090.007) had worse prognosis.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>\nCMR<\/jats:styled-content>\u2010derived RV TPER<\/jats:styled-content> and TPER<\/jats:styled-content>\/TCC<\/jats:styled-content> can reflect RV<\/jats:styled-content> early systolic function, and may be promising predictors for long\u2010term prognosis in IPAH<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12861","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T12:32:52Z","timestamp":1469104372000},"page":"172-178","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic value of right ventricular ejection\/filling parameters in IPAH<\/scp> using cardiac magnetic resonance: A prospective pilot study"],"prefix":"10.1111","volume":"22","author":[{"given":"Wen","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Gu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010Hai","family":"Ni","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Ming","family":"Xiong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Guo","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.027"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7133.2010.00202.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200811-1691OC"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00292.2003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","unstructured":"PennellDJ SechtemUP HigginsCB ManningWJ PohostGM RademakersFE vanRossumAC ShawLJ YucelEK;Society for Cardiovascular Magnetic Resonance;Working Group on Cardiovascular Magnetic Resonance of the European Society of Cardiology. 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