{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:32:27Z","timestamp":1777465947724,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Queensland Health Research Practitioner Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"\nABSTRACT<\/jats:styled-content>\n<\/jats:title>Background and objective<\/jats:title>The 6\u2010min walk test (6MWT<\/jats:styled-content>) is the most widely utilized method of assessing exercise capacity in pulmonary arterial hypertension (PAH<\/jats:styled-content>). Cardiopulmonary exercise testing has the advantage of providing additional physiological information over 6MWT<\/jats:styled-content>. The goals of our study were to describe the addition of gas exchange measurements to 6MWT<\/jats:styled-content> and to determine how these parameters were related to the severity of PAH<\/jats:styled-content> in three major subgroups of PAH<\/jats:styled-content> (idiopathic (IPAH<\/jats:styled-content>), connective tissue disease\u2010related (CTPAH<\/jats:styled-content>) and congenital heart disease\u2010related (CHPAH<\/jats:styled-content>)).<\/jats:p><\/jats:sec>Methods<\/jats:title>Seventy\u2010six PAH<\/jats:styled-content> patients (IPAH<\/jats:styled-content>, n<\/jats:italic>\u2009=\u200928; CTPAH<\/jats:styled-content>, n<\/jats:italic>\u2009=\u200924; CHPAH<\/jats:styled-content>, n<\/jats:italic>\u2009=\u200924) completed the 6MWT<\/jats:styled-content> with simultaneous gas exchange measurements. The 6\u2010min walk distance (6MWD<\/jats:styled-content>), oxygen uptake (\nO2<\/jats:sub>\n<\/jats:styled-content>), carbon dioxide production (\nCO2<\/jats:sub>\n<\/jats:styled-content>), oxygen saturation, minute ventilation to carbon dioxide output (\nE<\/jats:sub>\/\nCO2<\/jats:sub>\n<\/jats:styled-content>) and end\u2010tidal partial pressure for carbon dioxide (PET<\/jats:sub>CO2<\/jats:sub>\n<\/jats:styled-content>) were compared between subgroups, different functional classes (FCs) and pharmacotherapy.<\/jats:p><\/jats:sec>Results<\/jats:title>Whilst no significant difference in 6MWT<\/jats:styled-content> was observed, absolute \nO2<\/jats:sub>\n<\/jats:styled-content> and \nCO2<\/jats:sub>\n<\/jats:styled-content> were higher for IPAH<\/jats:styled-content> (P<\/jats:italic>\u2009<\u20090.05). Differences were removed when \nO2<\/jats:sub>\n<\/jats:styled-content> and \nCO2<\/jats:sub>\n<\/jats:styled-content> were expressed relative to body mass (i.e. mL\/kg\/min). CHPAH<\/jats:styled-content> had the most significant desaturation during 6MWT<\/jats:styled-content> (CPAH<\/jats:styled-content>: 73\u2009\u00b1\u200915%; CTPAH<\/jats:styled-content>: 90\u2009\u00b1\u20098%, IPAH<\/jats:styled-content>: 92\u2009\u00b1\u20098%, P<\/jats:italic>\u2009<\u20090.01). There was no difference in \nE<\/jats:sub>\/\nCO2<\/jats:sub>\n<\/jats:styled-content> and PET<\/jats:sub>CO2<\/jats:sub>\n<\/jats:styled-content> between groups; however, New York Health Association (NYHA<\/jats:styled-content>) FC II<\/jats:styled-content> performed better than FC III<\/jats:styled-content> subjects in 6MWT<\/jats:styled-content> with lower \nE<\/jats:sub>\/\nCO2<\/jats:sub>\n<\/jats:styled-content> and higher end\u2010exercise PET<\/jats:sub>CO2<\/jats:sub>\n<\/jats:styled-content>. Similarly, individuals on more advanced pharmacotherapy (triple therapy vs monotherapy) had poorer gas exchange during exercise.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Whilst 6MWT<\/jats:styled-content> and gas exchange did not differentiate between PAH<\/jats:styled-content> groups, individuals with more severe disease and on more advanced pharmacotherapy had poorer gas exchange during exercise.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12868","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T02:56:45Z","timestamp":1471402605000},"page":"165-171","source":"Crossref","is-referenced-by-count":10,"title":["Gas exchange responses during 6\u2010min walk test in patients with pulmonary arterial hypertension"],"prefix":"10.1111","volume":"22","author":[{"given":"Norman R.","family":"Morris","sequence":"first","affiliation":[{"name":"School of Allied Health Sciences, Menzies Health Institute Queensland Griffith University Gold Coast Queensland Australia"},{"name":"Queensland Lung Transplant Service The Prince Charles Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Seale","sequence":"additional","affiliation":[{"name":"Queensland Lung Transplant Service The Prince Charles Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Harris","sequence":"additional","affiliation":[{"name":"Queensland Lung Transplant Service The Prince Charles Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Hall","sequence":"additional","affiliation":[{"name":"Queensland Lung Transplant Service The Prince Charles Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron C. 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