{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:14:58Z","timestamp":1773281698073,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,11]],"date-time":"2016-09-11T00:00:00Z","timestamp":1473552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Irish Thoracic Society Research Fellowship"},{"name":"Health Research Board of Ireland"},{"name":"Cystic Fibrosis Association of Ireland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>\n<jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content>\n<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Acute exacerbations of cystic fibrosis (<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>) occur frequently throughout the course of the disease. Dyspnoea is the most common and distressing symptom experienced by patients during these episodes. We tested the hypothesis that pulmonary hyperinflation is an important determinant of dyspnoea severity during acute exacerbations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied patients during an acute exacerbation of <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>. Lung volumes, spirometry and dyspnoea scores were measured at Day 0, Day 7, at the end of treatment (<jats:styled-content style=\"fixed-case\">EOT<\/jats:styled-content>) and 14\u2009days following the <jats:styled-content style=\"fixed-case\">EOT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the start of treatment, mean residual volume (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>)\/total lung capacity (<jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content>) was 54.9%, which decreased significantly with treatment, as did vital capacity (<jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>), inspiratory capacity (<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>) and dyspnoea scores. IC was the only independent predictor of dyspnoea severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates significant improvements in hyperinflation, spirometry and dyspnoea scores with treatment of acute exacerbations of <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>. Hyperinflation, rather than airflow limitation, may contribute towards the increased dyspnoea during exacerbations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12885","type":"journal-article","created":{"date-parts":[[2016,9,11]],"date-time":"2016-09-11T11:32:40Z","timestamp":1473593560000},"page":"141-148","source":"Crossref","is-referenced-by-count":12,"title":["Relationship between pulmonary hyperinflation and dyspnoea severity during acute exacerbations of cystic fibrosis"],"prefix":"10.1111","volume":"22","author":[{"given":"Trevor T.","family":"Nicholson","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine St. Vincent's University Hospital  Dublin Ireland"},{"name":"National Referral Centre for Adult Cystic Fibrosis St. Vincent's University Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Barry","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine St. Vincent's University Hospital  Dublin Ireland"},{"name":"National Referral Centre for Adult Cystic Fibrosis St. Vincent's University Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre F.","family":"Waterhouse","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine St. Vincent's University Hospital  Dublin Ireland"},{"name":"National Referral Centre for Adult Cystic Fibrosis St. Vincent's University Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine M.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine St. Vincent's University Hospital  Dublin Ireland"},{"name":"National Referral Centre for Adult Cystic Fibrosis St. Vincent's University Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward F.","family":"McKone","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine St. Vincent's University Hospital  Dublin Ireland"},{"name":"National Referral Centre for Adult Cystic Fibrosis St. Vincent's University Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles G.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine St. Vincent's University Hospital  Dublin Ireland"},{"name":"National Referral Centre for Adult Cystic Fibrosis St. Vincent's University Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.060889"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.1.64"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.117288"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.09.024"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204303261804"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.04.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2007.06.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409083311003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400104"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512073332307"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00059404"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607183350307"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202538"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.07.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20277"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.6.2215"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(97)90135-9"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2004.11.004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00220702"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00045606"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/252345"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2010.12.006"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01946"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2013.04.010"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00475.2004"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.46.246.144"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21329"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200508-093DO"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.5.9804004"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16b14.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1987.135.6.1229"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034505"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035005"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.1.150"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-138"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.06.028"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.6.1506"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200303-398OC"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.5.8912758"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212173272504"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-201747"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.2.7842217"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.12885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.12885","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.12885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:55:04Z","timestamp":1695473704000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.12885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,11]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/resp.12885"],"URL":"https:\/\/doi.org\/10.1111\/resp.12885","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,11]]}}}