{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T12:16:24Z","timestamp":1770552984467,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006538","name":"Vanderbilt University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006538","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title><jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content><\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Respiratory symptoms including wheezing are common in adults with sickle cell anaemia (<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>), even in the absence of asthma. However, the prevalence of spirometry changes and respiratory symptoms in adults with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a cross\u2010sectional study design, we tested the hypothesis that adults with <jats:styled-content style=\"fixed-case\">SCA (cases)<\/jats:styled-content> would have higher rates of lower airway obstruction and wheezing than those without <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> (controls) using the American Thoracic Society Division of Lung Diseases\u2019 questionnaire. Patients were adults with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> aged between 18 and 65 years. Controls were consecutive unselected individuals without <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> who presented to an outpatient general medicine clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 150 adults with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> and 287 consecutive controls without <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>. The median age was 23.0 and 27.0 years for adults with and without <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>, respectively. Cases were more likely to report cough without a cold (35.0% vs 18.6%, <jats:italic>P<\/jats:italic> &lt; 0.001), lower forced expiratory volume in 1 s (<jats:styled-content style=\"fixed-case\">FEV<jats:sub>1<\/jats:sub>\n<\/jats:styled-content>) % predicted (70.1% vs 82.1%, <jats:italic>P<\/jats:italic> = 0.001) and lower forced vital capacity (<jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content>) % predicted (67.4% vs 74.9%, <jats:italic>P<\/jats:italic> = 0.001) than controls. In the multivariable model, wheezing was significantly associated with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> status (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.69, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.08\u20132.65, <jats:italic>P<\/jats:italic> = 0.024). Similarly, <jats:styled-content style=\"fixed-case\">FEV<jats:sub>1<\/jats:sub>\n<\/jats:styled-content>% predicted was significantly associated with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> status and wheezing (<jats:italic>P<\/jats:italic> = 0.001 for both).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adults with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> experience a higher rate of wheezing and impaired respiratory functions compared with controls from the same region.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12895","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T10:18:15Z","timestamp":1474539495000},"page":"284-288","source":"Crossref","is-referenced-by-count":5,"title":["Higher prevalence of wheezing and lower FEV1 and FVC percent predicted in adults with sickle cell anaemia: A cross\u2010sectional study"],"prefix":"10.1111","volume":"22","author":[{"given":"Baba M.","family":"Musa","sequence":"first","affiliation":[{"name":"Department of Medicine Bayero University\/Aminu Kano Teaching Hospital  Kano Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najibah A.","family":"Galadanci","sequence":"additional","affiliation":[{"name":"Department of Haematology and Blood Transfusion Bayero University\/Aminu Kano Teaching Hospital  Kano Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Rodeghier","sequence":"additional","affiliation":[{"name":"Rodeghier Consultants  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Debaun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Vanderbilt and Meharry Sickle Cell Disease Center of Excellence Vanderbilt University School of Medicine  Nashville Tennessee USA"},{"name":"Vanderbilt and Meharry Sickle Cell Disease Center of Excellence Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200203000-00005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.2.643.643"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422502"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22098"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12049"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2015.03.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-132506"},{"key":"e_1_2_7_9_1","first-page":"1","article-title":"Epidemiology Standardization Project (American Thoracic Society)","volume":"118","author":"Ferris BG","year":"1978","journal-title":"Am. 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