{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T15:05:42Z","timestamp":1782572742044,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Diaphragm function might be useful to predict nocturnal oxygen desaturation in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>. Ultrasonography has been widely used for the assessment of the diaphragm. We aimed to investigate the relationship between the contractile capability of the diaphragm assessed by ultrasonography and the nocturnal percutaneous arterial oxygen saturation (NSpO<jats:sub>2<\/jats:sub>) in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight male patients with <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> (age, 73 \u00b1 7 years; forced expiratory volume in 1 s (<jats:styled-content style=\"fixed-case\">FEV<jats:sub>1<\/jats:sub>\n<\/jats:styled-content>), 54.2 \u00b1 17.0% predicted) were included. The thickness of the diaphragm (<jats:styled-content style=\"fixed-case\">Tdi<\/jats:styled-content>) was assessed by ultrasonography. We calculated the change ratio of Tdi at the end of maximal inspiration and expiration (%\u0394Tdi). The mean value of <jats:styled-content style=\"fixed-case\">NSpO<jats:sub>2<\/jats:sub>\n<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NSpO<jats:sub>2mean<\/jats:sub>\n<\/jats:styled-content>), the percentage of total sleep time (<jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>) with desaturation above 4% (<jats:styled-content style=\"fixed-case\">DA4<\/jats:styled-content>%) and the percentage of <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> with saturation below 90% (<jats:styled-content style=\"fixed-case\">SB90<\/jats:styled-content>%) were measured by overnight oximetry. Daytime arterial oxygen pressure (<jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub>\n<\/jats:styled-content>) and maximal inspiratory mouth pressure (<jats:styled-content style=\"fixed-case\">PI<jats:sub>max<\/jats:sub>\n<\/jats:styled-content>) were also measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All participants had mild or no daytime hypoxaemia (<jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub>\n<\/jats:styled-content>, 77.3 \u00b1 8.6 mm Hg). The <jats:styled-content style=\"fixed-case\">NSpO<jats:sub>2mean<\/jats:sub>\n<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">DA4<\/jats:styled-content>% and <jats:styled-content style=\"fixed-case\">SB90<\/jats:styled-content>% were significantly correlated with %<jats:styled-content style=\"fixed-case\">\u0394Tdi<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub>\n<\/jats:styled-content>, %<jats:styled-content style=\"fixed-case\">PI<jats:sub>max<\/jats:sub>\n<\/jats:styled-content> of the predicted value and the Global Initiative for Chronic Obstructive Lung Disease (<jats:styled-content style=\"fixed-case\">GOLD<\/jats:styled-content>) stage. The %<jats:styled-content style=\"fixed-case\">\u0394Tdi<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub>\n<\/jats:styled-content> were predictors of <jats:styled-content style=\"fixed-case\">NSpO<jats:sub>2<\/jats:sub>mean<\/jats:styled-content> by multiple regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggested a close relationship between the <jats:styled-content style=\"fixed-case\">NSpO<jats:sub>2<\/jats:sub>\n<\/jats:styled-content> and the contractile capability of the diaphragm assessed by ultrasonography in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>. The %<jats:styled-content style=\"fixed-case\">\u0394Tdi<\/jats:styled-content> combined with <jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub>\n<\/jats:styled-content> might predict <jats:styled-content style=\"fixed-case\">NSpO<jats:sub>2<\/jats:sub>\n<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients with mild or no daytime hypoxaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12897","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T14:57:21Z","timestamp":1473433041000},"page":"301-306","source":"Crossref","is-referenced-by-count":23,"title":["Contractile capability of the diaphragm assessed by ultrasonography predicts nocturnal oxygen saturation in COPD"],"prefix":"10.1111","volume":"22","author":[{"given":"Kazuki","family":"Okura","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Akita City Hospital  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuyoshi","family":"Kawagoshi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Akita City Hospital  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Akita City Hospital  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiyu","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Akita City Hospital  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Akita City Hospital  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kashiwagura","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Akita City Hospital  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsunobu","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Akita City Hospital  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Satake","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Akita University Graduate School of Health Sciences  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanobu","family":"Shioya","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Akita University Graduate School of Health Sciences  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0640213"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.55.3.669"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.54.3.632"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.4.1011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.65.3.1196"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.51.3.557"},{"key":"e_1_2_7_8_1","first-page":"909","article-title":"Control of breathing during sleep","volume":"118","author":"Phillipson EA","year":"1978","journal-title":"Am. 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