{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:08:31Z","timestamp":1770448111463,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T00:00:00Z","timestamp":1473724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Scientific Research (C)","award":["25515004"],"award-info":[{"award-number":["25515004"]}]},{"name":"VA Research Service"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"ABSTRACT<\/jats:title>Background and objective<\/jats:title>The standard therapy for obstructive sleep apnoea (OSA<\/jats:styled-content>) is continuous positive airway pressure (CPAP<\/jats:styled-content>) therapy. However, long\u2010term adherence remains at ~50% despite improvements in behavioural and educational interventions. Based on prior work, we explored whether regularity of breathing during wakefulness might be a physiologic predictor of CPAP<\/jats:styled-content> adherence.<\/jats:p><\/jats:sec>Methods<\/jats:title>Of the 117 consecutive patients who were diagnosed with OSA<\/jats:styled-content> and prescribed CPAP<\/jats:styled-content>, 79 CPAP<\/jats:styled-content> na\u00efve patients were enrolled in this prospective study. During CPAP<\/jats:styled-content> initiation, respiratory signals were collected using respiratory inductance plethysmography while wearing CPAP<\/jats:styled-content> during wakefulness in a seated position. Breathing regularity was assessed by the coefficient of variation (CV<\/jats:styled-content>) for breath\u2010by\u2010breath estimated tidal volume (VT<\/jats:sub>\n<\/jats:styled-content>) and total duration of respiratory cycle (Ttot). In a derivation group (n<\/jats:italic> = 36), we determined the cut\u2010off CV<\/jats:styled-content> value which predicted poor CPAP<\/jats:styled-content> adherence at the first month of therapy, and verified the validity of this predetermined cut\u2010off value in the remaining participants (validation group; n<\/jats:italic> = 43).<\/jats:p><\/jats:sec>Results<\/jats:title>In the derivation group, the CV<\/jats:styled-content> for estimated VT<\/jats:sub>\n<\/jats:styled-content> was significantly higher in patients with poor adherence than with good adherence (median (interquartile range): 44.2 (33.4\u201357.4) vs 26.0 (20.4\u201333.2), P<\/jats:italic> < 0.001). The CV<\/jats:styled-content> cut\u2010off value for estimated VT<\/jats:sub>\n<\/jats:styled-content> for poor CPAP<\/jats:styled-content> adherence was 34.0, according to a receiver\u2010operating characteristic (ROC) curve. In the validation group, the CV<\/jats:styled-content> value for estimated VT<\/jats:sub>\n<\/jats:styled-content> >34.0 confirmed to be predicting poor CPAP<\/jats:styled-content> adherence (sensitivity, 0.78; specificity, 0.83).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>At the initiation of therapy, breathing regularity during wakefulness while wearing CPAP<\/jats:styled-content> is an objective predictor of short\u2010term CPAP<\/jats:styled-content> adherence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12900","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T14:06:42Z","timestamp":1473775602000},"page":"386-393","source":"Crossref","is-referenced-by-count":7,"title":["Variability of breathing during wakefulness while using CPAP predicts adherence"],"prefix":"10.1111","volume":"22","author":[{"given":"Yukio","family":"Fujita","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine (Department of Respiratory Medicine) Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoo","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine (Department of Respiratory Medicine) Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Uyama","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine (Department of Respiratory Medicine) Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Kumamoto","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine (Department of Respiratory Medicine) Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Koyama","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine (Department of Respiratory Medicine) Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine (Department of Respiratory Medicine) Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kingman P.","family":"Strohl","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine Case Western Reserve University and Louis Stokes Cleveland VA Medical Center Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine (Department of Respiratory Medicine) Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4654"},{"key":"e_1_2_7_3_1","first-page":"1071","article-title":"Sleep disordered breathing and mortality: eighteen\u2010year follow\u2010up of the Wisconsin sleep cohort","volume":"31","author":"Young T","year":"2008","journal-title":"Sleep"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-119MG"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.5.623"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.5.7735625"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.6.799"},{"key":"e_1_2_7_9_1","first-page":"320","article-title":"Early CPAP use identifies subsequent adherence to CPAP therapy","volume":"30","author":"Budhiraja R","year":"2007","journal-title":"Sleep"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00114603"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2001.0197"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.2.429"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.4.9807111"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(00)00063-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.2.430"},{"key":"e_1_2_7_16_1","first-page":"13","article-title":"Determinants affecting initiation of continuous positive airway pressure treatment","volume":"7","author":"Brin YS","year":"2005","journal-title":"Isr. 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