{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:51:12Z","timestamp":1791197472498,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF\u20102007\u20100054930"],"award-info":[{"award-number":["NRF\u20102007\u20100054930"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"\nABSTRACT<\/jats:styled-content>\n<\/jats:title>Background and objective<\/jats:title>Recognition of patients at risk of asthma exacerbation is important for future asthma care and improved outcome. The aim of the present study was to see whether measurements of bronchodilator response (BDR<\/jats:styled-content>) and fractional exhaled nitric oxide (FeNO<\/jats:styled-content>) in combination provide prognostic information superior to either measurement alone in children with atopic asthma.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 201 atopic children aged 8\u201316\u2009years with intermittent or mild persistent asthma were included. Pulmonary function tests including BDR<\/jats:styled-content> and FeNO<\/jats:styled-content> were serially monitored 10 times or more over 2\u2009years when subjects were not receiving controller medications. After completion of monitoring, 1\u2010year observation for a loss of asthma control was performed.<\/jats:p><\/jats:sec>Results<\/jats:title>During the monitoring period, positive BDRs<\/jats:styled-content> (\u226512% in forced expiratory volume in 1\u2009s (FEV1<\/jats:sub>\n<\/jats:styled-content>) from pre\u2010bronchodilator value) and FeNO<\/jats:styled-content> higher than 35 parts per billion (ppb) were observed at least once in 59% and 77% of participants. When analysed as continuous variables, both BDR<\/jats:styled-content> (hazard ratio (HR<\/jats:styled-content>): 1.21; 95% CI<\/jats:styled-content>: 1.04\u20131.41; P<\/jats:italic>\u2009=\u20090.014) and FeNO<\/jats:styled-content> (HR<\/jats:styled-content>: 1.27; 95% CI<\/jats:styled-content>: 1.09\u20131.49; P<\/jats:italic>\u2009=\u20090.003) were associated with increased risks for a control loss. Compared with patients showing either positive BDRs<\/jats:styled-content> (HR<\/jats:styled-content>: 3.19; 95% CI<\/jats:styled-content>: 1.05\u20139.64) or FeNO<\/jats:styled-content> higher than 35\u2009ppb (HR<\/jats:styled-content>: 4.70; 95% CI<\/jats:styled-content>: 1.68\u201313.11), patients with both findings (HR<\/jats:styled-content>: 7.08; 95% CI<\/jats:styled-content>: 2.57\u201319.49) had greater risks for a control loss.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These data support that combined use of BDR<\/jats:styled-content> and FeNO<\/jats:styled-content> measurements can modify predictive risk obtained from either measurement alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12934","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T13:12:51Z","timestamp":1477487571000},"page":"466-472","source":"Crossref","is-referenced-by-count":17,"title":["Combined use of fractional exhaled nitric oxide and bronchodilator response in predicting future loss of asthma control among children with atopic asthma"],"prefix":"10.1111","volume":"22","author":[{"given":"Je\u2010Kyung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pediatrics Chungbuk National University Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Yub","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chungbuk National University Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine College of Medicine and Medical Research Institute, Chungbuk National University Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Yong","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine College of Medicine and Medical Research Institute, Chungbuk National University Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn\u2010Soo","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Chungbuk National University Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69283-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32834db288"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-060ST"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.056093"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.5.2012125"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2015.03.003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.03.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02734.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.48.7.722"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-201966"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.09.004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.11.029"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.01.050"},{"key":"e_1_2_7_16_1","first-page":"276","article-title":"Independent influence of reversibility of air\u2010flow obstruction and nonspecific hyperreactivity on the long\u2010term course of lung function in chronic air\u2010flow obstruction","volume":"134","author":"Postma Da DVK","year":"1986","journal-title":"Am. 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