{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:13:22Z","timestamp":1788394402831,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T00:00:00Z","timestamp":1478563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>\n<jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content>\n<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Few studies have analysed a large number of patients with necrotizing pneumonia (<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>) diagnosed based on computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) scans. The aim of the present study was to document the incidence and clinical features of <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> in patients with community\u2010acquired pneumonia (<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study was conducted on <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> patients who had been admitted to a tertiary referral centre and who had available enhanced <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scan images. Patients were allocated into <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> groups, and they were compared with respect to various clinical variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 830 patients included in the present study, necrotizing change was observed in 103 patients (12%). Patients with <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> experienced more symptoms of pneumonia, had higher blood levels of inflammatory markers and more often required pleural drainage compared to patients with non\u2010<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>. Although the use of mechanical ventilation, vasopressor infusion, 30\u2010day mortality, in\u2010hospital mortality and clinical deterioration did not differ between the <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> groups, the median length of hospital stay (<jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>) was significantly longer in the <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> group. Multivariate analysis using Cox proportional hazards model showed that necrotizing change independently predicted <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> affects approximately one\u2010tenth of hospitalized <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> patients. It may be associated with more severe clinical manifestations and may increase the need for pleural drainage. <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> was found to be an independent predictor of <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>, but not of mortality in <jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12943","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T14:55:11Z","timestamp":1478616911000},"page":"551-558","source":"Crossref","is-referenced-by-count":22,"title":["Clinical relevance of necrotizing change in patients with community\u2010acquired pneumonia"],"prefix":"10.1111","volume":"22","author":[{"given":"Hyewon","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Kyungpook National University School of Medicine  Daegu 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