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Despite applicability in both clinical and non\u2010clinical populations, with different pre\u2010test asthma probabilities, differences in diagnostic properties have not been well explored. This study aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During the 22\u2010year follow\u2010up of the Western Australian Pregnancy (Raine) Cohort, 772 participants (384 males) completed mannitol challenge and skin prick testing and respiratory health questionnaires, of whom 148 reporting wheeze in the past 12\u2009months were included in a wheezing subset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Responsiveness to mannitol had low sensitivity (19%) and high specificity (97%) to identify current asthma in the complete cohort, with positive and negative predictive values (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content>) of 45% and 92%, respectively. Within the wheezing subset, sensitivity (19%) and specificity (94%) remained similar, but <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> increased to 79%, and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> decreased to 52%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings support previously reported high specificity and good <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> for mannitol challenge testing in symptomatic wheezing populations, and highlight the need for caution when interpreting mannitol test results in non\u2010clinical populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12955","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T05:03:58Z","timestamp":1480914238000},"page":"678-683","source":"Crossref","is-referenced-by-count":6,"title":["Mannitol challenge testing for asthma in a community cohort of young adults"],"prefix":"10.1111","volume":"22","author":[{"given":"Elisha C.","family":"White","sequence":"first","affiliation":[{"name":"Telethon Kids Institute, Perth  Perth Western Australia Australia"},{"name":"Centre for Child Health Research University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"de Klerk","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth  Perth Western Australia Australia"},{"name":"Centre for Child Health Research University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Hantos","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth  Perth Western Australia Australia"},{"name":"Department of Medical Physics and Informatics University of Szeged  Szeged Hungary"},{"name":"Children's Lung Environment and Asthma Research Team University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Priston","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elysia M.","family":"Hollams","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth  Perth Western Australia Australia"},{"name":"Centre for Child Health Research University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"James","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Physiology\/West Australian Sleep Disorders Research Institute Sir Charles Gardiner Hospital  Perth Western Australia Australia"},{"name":"School of Medicine and Pharmacology University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Sly","sequence":"additional","affiliation":[{"name":"Children's Lung Environment and Asthma Research Team University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick G.","family":"Holt","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth  Perth Western Australia Australia"},{"name":"Centre for Child Health Research University of Western Australia  Perth Western Australia Australia"},{"name":"Children's Lung Environment and Asthma Research Team University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham L.","family":"Hall","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute, Perth  Perth Western Australia Australia"},{"name":"Centre for Child Health Research University of Western Australia  Perth Western Australia Australia"},{"name":"School of Physiotherapy and Exercise Science, Faculty of Health Sciences Curtin University  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00460"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"AndersonSD CharltonB WeilerJM NicholsS SpectorSL PearlmanDS;A305 Study Group. 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