{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:35:34Z","timestamp":1790260534660,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000351","name":"British Lung Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000351","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004264","name":"Robert Luff Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000769","name":"University Of Oxford","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007582","name":"Alberta Health Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"\nABSTRACT<\/jats:styled-content>\n<\/jats:title>Background and objective<\/jats:title>Malignant pleural effusion is associated with morbidity and mortality. A randomized controlled trial previously compared clinical outcomes and resource use with indwelling pleural catheter (IPC<\/jats:styled-content>) and talc pleurodesis in this population. Using unpublished quality of life data, we estimate the cost\u2010effectiveness of IPC<\/jats:styled-content> compared with talc pleurodesis.<\/jats:p><\/jats:sec>Methods<\/jats:title>Healthcare utilization and costs were captured during the trial. Utility weights produced by the EuroQol<\/jats:styled-content> Group five\u2010dimensional three\u2010level questionnaire and survival were used to determine quality\u2010adjusted life\u2010years (QALYs<\/jats:styled-content>) gained. The incremental cost\u2010effectiveness ratio (ICER<\/jats:styled-content>) was calculated over the 1\u2010year trial period. Sensitivity analysis used patient survival data and modelled additional nursing time required per week for catheter drainage.<\/jats:p><\/jats:sec>Results<\/jats:title>Utility scores, cost and QALYs<\/jats:styled-content> gained did not differ significantly between groups. The ICER<\/jats:styled-content> for IPC<\/jats:styled-content> compared with talc was favorable at $US10\u2009870 per QALY<\/jats:styled-content> gained. IPC<\/jats:styled-content> was less costly with a probability exceeding 95% of being cost\u2010effective when survival was <14\u2009weeks, and was more costly when 2\u2010h nursing time per week was assumed for catheter drainage.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>\nIPC<\/jats:styled-content> is cost\u2010effective when compared with talc, although substantial uncertainty exists around this estimate. IPC<\/jats:styled-content> appears most cost\u2010effective in patients with limited survival. If significant nursing time is required for catheter drainage, IPC<\/jats:styled-content> becomes less likely to be cost\u2010effective. Either therapy may be considered as a first\u2010line option in treating malignant pleural effusion in patients without history of prior pleurodesis, with consideration for patient survival, support and preferences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12962","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T16:00:44Z","timestamp":1481990444000},"page":"764-770","source":"Crossref","is-referenced-by-count":57,"title":["Cost\u2010effectiveness of indwelling pleural catheter compared with talc in malignant pleural effusion"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1370-2787","authenticated-orcid":false,"given":"Jordan A.P.","family":"Olfert","sequence":"first","affiliation":[{"name":"Department of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika D.","family":"Penz","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braden J.","family":"Manns","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Calgary Calgary Alberta Canada"},{"name":"Department of Community Health Sciences University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor K.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Oxford Respiratory Trials Unit University of Oxford Oxford UK"},{"name":"Norfolk and Norwich University Hospital NHS Foundation Trust Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E.","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University Hospital of Wales Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Miller","sequence":"additional","affiliation":[{"name":"Research Department of Infection and Population Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Luengo\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Health Economics Research Centre, Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Gao","sequence":"additional","affiliation":[{"name":"Analytics (DIMR) Alberta Health Services Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najib M.","family":"Rahman","sequence":"additional","affiliation":[{"name":"Oxford Respiratory Trials Unit University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.5.ats8-00"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90154-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136994"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5535"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2481"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","unstructured":"PenzED MishraEK DaviesHE MannsBJ MillerRF RahmanNM.Comparing the quality of life and cost\u2010effectiveness of indwelling pleural catheter vs. talc pleurodesis for malignant pleural effusions [abstract spoken presentation].Thorax2013;68(Suppl 3): A42\u2013A43.","DOI":"10.1136\/thoraxjnl-2013-204457.86"},{"key":"e_1_2_8_8_1","unstructured":"Office for National Statistics. 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