{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:28:41Z","timestamp":1793143721511,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T00:00:00Z","timestamp":1481241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004853","name":"The Chinese University of Hong Kong","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"\nABSTRACT<\/jats:styled-content>\n<\/jats:title>Background and objective<\/jats:title>Obstructive sleep apnoea (OSA<\/jats:styled-content>) is associated with an increased prevalence of metabolic syndrome. This study explores the effects of continuous positive airway pressure (CPAP<\/jats:styled-content>) for patients with OSA<\/jats:styled-content> on visceral and mesenteric fat thickness, carotid intima\u2010media thickness (IMT<\/jats:styled-content>) and adipokines.<\/jats:p><\/jats:sec>Methods<\/jats:title>A randomized controlled study was conducted at a teaching hospital on 90 patients newly diagnosed with OSA<\/jats:styled-content> to receive either therapeutic CPAP<\/jats:styled-content> or subtherapeutic CPAP<\/jats:styled-content> for 3\u2009months. Visceral fat thickness and carotid IMT<\/jats:styled-content> were measured with B\u2010mode ultrasound; adipokine levels were assessed at baseline and 3\u2009months.<\/jats:p><\/jats:sec>Results<\/jats:title>Altogether, 45 patients received therapeutic CPAP<\/jats:styled-content> and 45 received subtherapeutic CPAP<\/jats:styled-content> without significant differences in age 50.3 (10.1) versus 48.7 (9.0) years, BMI<\/jats:styled-content> 28.2 (3.9) versus 28.2 (4.5) kg\/m2<\/jats:sup>, Epworth Sleepiness Scale (ESS<\/jats:styled-content>) 12.4 (5.9) versus 11.3 (4.7), apnoea\u2013hypopnoea index (AHI<\/jats:styled-content>) 30.6 (21.4) versus 35.2 (25.5) \/h, minimum SaO2<\/jats:sub>\n<\/jats:styled-content> 79.6 (10.8) versus 76.7 (12.4) % and existing co\u2010morbidities. CPAP<\/jats:styled-content> usage was therapeutic 4.2 (2.1) versus subtherapeutic 4.1 (2.0) h\/night over 3\u2009months. Adiponectin and irisin levels changed significantly following therapeutic CPAP<\/jats:styled-content> for 3\u2009months versus subtherapeutic CPAP<\/jats:styled-content> (\u22121.6 vs 7.3, P<\/jats:italic>\u2009=\u20090.042; 0.1 vs \u22120.1, P<\/jats:italic>\u2009=\u20090.028 respectively) while only serum level of monocyte chemotactic protein 1 (MCP<\/jats:styled-content>\u20101) at baseline was positively correlated with AHI<\/jats:styled-content> (r\u2009=\u20090.278). No significant changes were observed in other adipokines, visceral fat thickness and IMT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Short\u2010term therapeutic CPAP<\/jats:styled-content> versus subtherapeutic CPAP<\/jats:styled-content> does not significantly reduce visceral fat thickness and IMT<\/jats:styled-content>, although it reduces adiponectin and increases irisin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12963","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T05:16:49Z","timestamp":1481260609000},"page":"786-792","source":"Crossref","is-referenced-by-count":24,"title":["Effects of CPAP therapy on visceral fat thickness, carotid intima\u2010media thickness and adipokines in patients with obstructive sleep apnoea"],"prefix":"10.1111","volume":"22","author":[{"given":"Susanna S.S.","family":"Ng","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric K.H.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Imaging & Interventional Radiology The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.W.","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-5846","authenticated-orcid":false,"given":"Tat\u2010On","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin\u2010Wang","family":"To","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken K.P.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Ngai","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing\u2010Ho","family":"Yip","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny W.S.","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Kwok","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.C.","family":"Hui","sequence":"additional","affiliation":[{"name":"Division of 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