{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:33:25Z","timestamp":1790624005846,"version":"4.1.0"},"reference-count":135,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T00:00:00Z","timestamp":1484784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Singapore Ministry of Health's National Medical Research Council (Transition Award)","award":["NMRC\/TA\/0048\/2016"],"award-info":[{"award-number":["NMRC\/TA\/0048\/2016"]}]},{"name":"National Health and Medical Research Council of Australia"},{"name":"Brawn Foundation of the Faculty of Health and Medicine"},{"DOI":"10.13039\/501100000774","name":"University of Newcastle","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000774","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Rainbow Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>There is currently enormous interest in studying the role of the microbiome in health and disease. Microbiome's role is increasingly being applied to respiratory diseases, in particular <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>, asthma, cystic fibrosis and bronchiectasis. The changes in respiratory microbiomes that occur in these diseases and how they are modified by environmental challenges such as cigarette smoke, air pollution and infection are being elucidated. There is also emerging evidence that gut microbiomes play a role in lung diseases through the modulation of systemic immune responses and can be modified by diet and antibiotic treatment. There are issues that are particular to the Asia\u2010Pacific region involving diet and prevalence of specific respiratory diseases. Each of these issues is further complicated by the effects of ageing. The challenges now are to elucidate the cause and effect relationships between changes in microbiomes and respiratory diseases and how to translate these into new treatments and clinical care. Here we review the current understanding and progression in these areas.<\/jats:p>","DOI":"10.1111\/resp.12971","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T01:28:19Z","timestamp":1484875699000},"page":"240-250","source":"Crossref","is-referenced-by-count":118,"title":["Microbiomes in respiratory health and disease: An Asia\u2010Pacific perspective"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0417-7607","authenticated-orcid":false,"given":"Sanjay H.","family":"Chotirmall","sequence":"first","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaan L.","family":"Gellatly","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs University of Newcastle and Hunter Medical Research Institute  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurtis F.","family":"Budden","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs University of Newcastle and Hunter Medical Research Institute  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miche\u00e1l","family":"Mac Aog\u00e1in","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakti D.","family":"Shukla","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs University of Newcastle and Hunter Medical Research Institute  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.A.","family":"Wood","sequence":"additional","affiliation":[{"name":"Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Hugenholtz","sequence":"additional","affiliation":[{"name":"Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Pethe","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Hansbro","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs University of Newcastle and Hunter Medical Research Institute  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-015-0094-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v6.i2.41"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2011.07.012"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11234"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.10.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2012.09.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2015.1078051"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-2075OC"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02284-14"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00037-15"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201210-1913OC"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004923"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00279.2015"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008578"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201304-0775OC"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/08958378.2015.1070220"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.142"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar\/ilv012"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.32"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8320"},{"key":"e_1_2_9_22_1","first-page":"1525","article-title":"JTD special edition \u2018Hot Topics in COPD\u2019\u2013the microbiome in COPD","volume":"6","author":"Chambers DC","year":"2014","journal-title":"J. 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