{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:44:47Z","timestamp":1791679487111,"version":"4.3.4"},"reference-count":104,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T00:00:00Z","timestamp":1486512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009734","name":"Olympus","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009734","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n ABSTRACT<\/jats:styled-content>\n <\/jats:title>\n \n Tissue diagnosis of peripheral pulmonary lesions (\n PPLs<\/jats:styled-content>\n ) can be challenging. In the past, flexible bronchoscopy was commonly performed for this purpose but its diagnostic yield is suboptimal. This has led to the development of new bronchoscopic modalities such as radial endobronchial ultrasound (R\u2010\n EBUS<\/jats:styled-content>\n ), electromagnetic navigation bronchoscopy (\n ENB<\/jats:styled-content>\n ) and virtual bronchoscopy (\n VB<\/jats:styled-content>\n ). We performed this meta\u2010analysis using data from previously published R\u2010\n EBUS<\/jats:styled-content>\n studies, to determine its diagnostic yield and other performance characteristics. Ovid\n MEDLINE<\/jats:styled-content>\n and\n PubMed<\/jats:styled-content>\n databases were searched for R\u2010\n EBUS<\/jats:styled-content>\n studies in September 2016. Diagnostic yield was calculated by dividing the number of successful diagnoses by the total number of lesions. Meta\u2010analysis was performed using\n MedCalc<\/jats:styled-content>\n (Version 16.8). Inverse variance weighting was used to aggregate diagnostic yield proportions across studies. Publication bias was assessed using funnel plot and Duval and Tweedie's test. 57 studies with a total of 7872 lesions were included in the meta\u2010analysis. These were published between October 2002 and August 2016. Overall weighted diagnostic yield for R\u2010\n EBUS<\/jats:styled-content>\n was 70.6% (95%\n CI<\/jats:styled-content>\n : 68\u201373.1%). The diagnostic yield was significantly higher for lesions >2\u2009cm in size, malignant in nature and those associated with a bronchus sign on computerized tomography (\n CT<\/jats:styled-content>\n ) scan. Diagnostic yield was also higher when R\u2010\n EBUS<\/jats:styled-content>\n probe was within the lesion as opposed to being adjacent to it. Overall complication rate was 2.8%. This is the largest meta\u2010analysis performed to date, assessing the performance of R\u2010\n EBUS<\/jats:styled-content>\n for diagnosing\n PPLs<\/jats:styled-content>\n . R\u2010\n EBUS<\/jats:styled-content>\n has a high diagnostic yield (70.6%) with a very low complication rate.\n <\/jats:p>","DOI":"10.1111\/resp.12980","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T07:56:46Z","timestamp":1486540606000},"page":"443-453","source":"Crossref","is-referenced-by-count":240,"title":["Radial endobronchial ultrasound for the diagnosis of peripheral pulmonary lesions:\n A<\/scp>\n systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9343-1074","authenticated-orcid":false,"given":"Muhammad S.","family":"Ali","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Trick","sequence":"additional","affiliation":[{"name":"Department of Medicine John H. Stroger, Jr. Hospital of Cook County Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin I.","family":"Mba","sequence":"additional","affiliation":[{"name":"Department of Medicine John H. Stroger, Jr. Hospital of Cook County Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divyanshu","family":"Mohananey","sequence":"additional","affiliation":[{"name":"Department of Hospital Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaskaran","family":"Sethi","sequence":"additional","affiliation":[{"name":"Department of Medicine John H. 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