{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T15:09:10Z","timestamp":1777820950722,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>\n<jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content>\n<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Whilst the impact of clinicopathological factors on the prognosis of malignant pleural mesothelioma (<jats:styled-content style=\"fixed-case\">MPM<\/jats:styled-content>) is well understood, socioeconomic and geographic factors have received less attention. We analysed the relationship between geographic and socioeconomic factors upon survival and treatment provision in a large series of patients with <jats:styled-content style=\"fixed-case\">MPM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed <jats:styled-content style=\"fixed-case\">MPM<\/jats:styled-content> patients awarded compensation between 2002 and 2009 with additional <jats:styled-content style=\"fixed-case\">MPM<\/jats:styled-content> incidence data from the New South Wales (<jats:styled-content style=\"fixed-case\">NSW<\/jats:styled-content>) Cancer Registry. The impact of geographic remoteness, distance from oncological multidisciplinary team (<jats:styled-content style=\"fixed-case\">MDT<\/jats:styled-content>) and Index of Relative Socioeconomic Advantage and Disadvantage (<jats:styled-content style=\"fixed-case\">IRSAD<\/jats:styled-content>) upon survival, clinical features and treatment received was analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 910 patients (67% residing in major cities; 92% &lt;50\u2009km from <jats:styled-content style=\"fixed-case\">MDT<\/jats:styled-content>). Median overall survival was 10.0\u2009months. On multivariate analysis, age &gt;70 (hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>)\u2009=\u20091.39), male gender (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2009=1.36), non\u2010epithelioid histological subtype (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2009=\u20092.18) and <jats:styled-content style=\"fixed-case\">IRSAD<\/jats:styled-content> status by decreasing quintile (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2009=\u20091.06) were independent prognostic factors. There was no significant advantage for patients residing in major cities (10.6\u2009months vs 8.8\u2009months; <jats:italic>P<\/jats:italic>\u2009=\u20090.162) or within 50\u2009km of <jats:styled-content style=\"fixed-case\">MDT<\/jats:styled-content> (10.3\u2009months vs 7.8\u2009months; <jats:italic>P<\/jats:italic>\u2009=\u20090.539). Patient's geographic location and distance to <jats:styled-content style=\"fixed-case\">MDT<\/jats:styled-content> did not impact chemotherapy, adjuvant radiotherapy or extrapleural pneumonectomy provision. Socioeconomically disadvantaged patients were significantly less likely to receive chemotherapy (37.4% vs 54.8%; <jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides evidence for differences in the treatment and survival according to socioeconomic status for compensated <jats:styled-content style=\"fixed-case\">MPM<\/jats:styled-content> patients in <jats:styled-content style=\"fixed-case\">NSW<\/jats:styled-content>. Further research is warranted to seek additional explanations for the differences noted by comparing the treatments and outcomes of compensated and non\u2010compensated <jats:styled-content style=\"fixed-case\">MPM<\/jats:styled-content> patients in <jats:styled-content style=\"fixed-case\">NSW<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.12981","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T10:23:03Z","timestamp":1485858183000},"page":"978-985","source":"Crossref","is-referenced-by-count":7,"title":["Geographic and socioeconomic factors in patients with malignant pleural mesothelioma in <scp>N<\/scp>ew <scp>S<\/scp>outh <scp>W<\/scp>ales and their impact upon clinical outcomes"],"prefix":"10.1111","volume":"22","author":[{"given":"Anthony","family":"Linton","sequence":"first","affiliation":[{"name":"Asbestos Diseases Research Institute  Sydney New South Wales Australia"},{"name":"Concord Cancer Centre Concord Hospital  Sydney New South Wales Australia"},{"name":"University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Soeberg","sequence":"additional","affiliation":[{"name":"Asbestos Diseases Research Institute  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Broome","sequence":"additional","affiliation":[{"name":"Public Health Observatory Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Kao","sequence":"additional","affiliation":[{"name":"Asbestos Diseases Research Institute  Sydney New South Wales Australia"},{"name":"University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Medical Oncology Chris O'Brien Lifehouse  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico","family":"van Zandwijk","sequence":"additional","affiliation":[{"name":"Asbestos Diseases Research Institute  Sydney New South Wales Australia"},{"name":"University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2012.03.001"},{"key":"e_1_2_7_3_1","first-page":"1125","article-title":"Asbestosis & pleural tumors","volume":"102","author":"Van Der Schoot HC","year":"1958","journal-title":"Ned. Tijdschr. Geneeskd."},{"key":"e_1_2_7_4_1","first-page":"93","article-title":"Cancer of pleura in pulmonary asbestosis determined morphologically in vivo","volume":"6","author":"Weiss A","year":"1953","journal-title":"Medizinische"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.478"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.066886"},{"key":"e_1_2_7_7_1","unstructured":"Australian Bureau of Statistics. Regional Population Growth Australia.2011 Cat. No. 3218.0 2012."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2012.02925.x"},{"key":"e_1_2_7_9_1","unstructured":"BegbieSUC. Cancer services to be proud of in rural Australia: lessons learnt from the Clinical Oncological Society of Australia Cancer Service Audit.Cancer Forum2007;31: 90\u20133."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja14.01217"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2004.tb06123.x"},{"key":"e_1_2_7_12_1","unstructured":"Australian Bureau of Statistics.Australian Statistical Geography Standard (ASGS) Vol. 5. Remoteness Areas. Commonwealth of Australia. ABS Canberra 2011."},{"key":"e_1_2_7_13_1","volume-title":"Census of Population and Housing: Socio\u2010Economic Indexes of Areas (SEIFA) Australia 2011","author":"Australian Bureau of Statistics","year":"2013"},{"key":"e_1_2_7_14_1","first-page":"1293","volume-title":"Cancer Medicine","author":"Chahinian AP","year":"2000"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.145"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.9.731"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001376"},{"key":"e_1_2_7_18_1","unstructured":"Australian Institute of Health and Welfare and Australasian Association of Cancer Registries. Cancer in Australia: An Overview 2014.Cancer Series No. 90 Cat. No. CAN 88. AIHW Canberra 2015."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2015.10.032"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.3049"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyh386"}],"container-title":["Respirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fresp.12981","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/resp.12981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T04:22:02Z","timestamp":1696047722000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/resp.12981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,31]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/resp.12981"],"URL":"https:\/\/doi.org\/10.1111\/resp.12981","archive":["Portico"],"relation":{},"ISSN":["1323-7799","1440-1843"],"issn-type":[{"value":"1323-7799","type":"print"},{"value":"1440-1843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,31]]}}}