{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:44:32Z","timestamp":1790361872843,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100003284","name":"Pulmonary Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003284","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1017802"],"award-info":[{"award-number":["GNT1017802"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\nABSTRACT<\/jats:styled-content>\n<\/jats:title>Background and objective<\/jats:title>Supplemental oxygen is commonly prescribed in patients with idiopathic pulmonary fibrosis (IPF<\/jats:styled-content>), although its benefits have not been proven. The aims of this study were to investigate the effect of oxygen on oxidative stress, cytokine production, skeletal muscle metabolism and physiological response to exercise in IPF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Eleven participants with IPF<\/jats:styled-content> received either oxygen, at an FiO2<\/jats:sub>\n<\/jats:styled-content> of 0.50, or compressed air for 1\u2009h at rest and during a cycle endurance test at 85% of peak work rate. Blood samples collected at rest and during exercise were analysed for markers of oxidative stress, skeletal muscle metabolism and cytokines. The protocol was repeated a week later with the alternate intervention.<\/jats:p><\/jats:sec>Results<\/jats:title>Compared with air, oxygen did not adversely affect biomarker concentrations at rest and significantly improved endurance time (mean difference\u2009=\u200999\u2009\u00b1\u200981s, P<\/jats:italic>\u2009=\u20090.002), dyspnoea (\u22121\u2009\u00b1\u20091\u2009U, P<\/jats:italic>\u2009=\u20090.02), systolic blood pressure (BP<\/jats:styled-content>; \u221211\u2009\u00b1\u200911\u2009mm Hg<\/jats:styled-content>, P<\/jats:italic>\u2009=\u20090.006), nadir oxyhaemoglobin saturation (SpO2<\/jats:sub>\n<\/jats:styled-content>; 8\u2009\u00b1\u20096%, P<\/jats:italic>\u2009=\u20090.001), SpO2<\/jats:sub>\n<\/jats:styled-content> at 2\u2010min (7\u2009\u00b1\u20096%, P<\/jats:italic>\u2009=\u20090.003) and 5\u2010min isotimes (5\u2009\u00b1\u20093, P<\/jats:italic>\u2009<\u20090.001) and peak exercise xanthine concentrations (\u221242\u2009\u00b1\u200973\u2009\u00b5mol\/L, P<\/jats:italic>\u2009=\u20090.03). Air significantly increased IL<\/jats:styled-content>\u201010 (5\u2009\u00b1\u20095\u2009pg\/mL<\/jats:styled-content>, P<\/jats:italic>\u2009=\u20090.04) at 2\u2010min isotime. Thiobarbituric acid\u2010reactive substances (TBARs<\/jats:styled-content>), IL<\/jats:styled-content>\u20106, TNF<\/jats:styled-content>\u2010\u03b1, creatine kinase, lactate, heart rate and fatigue did not differ between the two interventions at any time point.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In patients with IPF<\/jats:styled-content>, breathing oxygen at FiO2<\/jats:sub><\/jats:styled-content> of 0.50 at rest seems safe. During exercise, oxygen improves exercise tolerance, alleviates exercise\u2010induced hypoxaemia and reduces dyspnoea. A potential relationship between oxygen administration and improved skeletal muscle metabolism should be explored in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/resp.13002","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T12:02:43Z","timestamp":1487764963000},"page":"957-964","source":"Crossref","is-referenced-by-count":73,"title":["Greater endurance capacity and improved dyspnoea with acute oxygen supplementation in idiopathic pulmonary fibrosis patients without resting hypoxaemia"],"prefix":"10.1111","volume":"22","author":[{"given":"Leona M.","family":"Dowman","sequence":"first","affiliation":[{"name":"Discipline of Physiotherapy La Trobe University, Alfred Centre Melbourne Victoria Australia"},{"name":"Department of Respiratory & Sleep Medicine Austin Health Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep Austin Health Melbourne Victoria Australia"},{"name":"Department of Physiotherapy Austin Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine F.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Respiratory & Sleep Medicine Austin Health Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep Austin Health Melbourne Victoria Australia"},{"name":"Department of Medicine University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Bozinovski","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences RMIT University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Vlahos","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences RMIT University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Gillies","sequence":"additional","affiliation":[{"name":"Discipline of Physiotherapy La Trobe University, Alfred Centre Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep Austin Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dodie","family":"Pouniotis","sequence":"additional","affiliation":[{"name":"Institute for Breathing and Sleep Austin Health Melbourne Victoria Australia"},{"name":"School of Health and Biomedical Sciences RMIT University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine J.","family":"Hill","sequence":"additional","affiliation":[{"name":"Institute for Breathing and Sleep Austin Health Melbourne Victoria Australia"},{"name":"Department of Physiotherapy Austin Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole S.L.","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Respiratory & Sleep Medicine Austin Health Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep Austin Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E","family":"Holland","sequence":"additional","affiliation":[{"name":"Discipline of Physiotherapy La Trobe University, Alfred Centre Melbourne Victoria Australia"},{"name":"Institute for Breathing and Sleep Austin Health Melbourne Victoria Australia"},{"name":"Department of Physiotherapy Alfred Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1897"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201403-0509PP"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.04.036"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.07.021"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200310-1465OC"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200209-1028OC"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.6.R1697"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.3.1031"},{"key":"e_1_2_7_11_1","first-page":"CD006322","article-title":"Pulmonary rehabilitation for interstitial lung disease","author":"Dowman L","year":"2014","journal-title":"Cochrane Database Syst. 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